NIA IMPACT Collaboratory

ISCB 2021 (Registration Closed): 42ND ANNUAL CONFERENCE OF THE INTERNATIONAL SOCIETY FOR CLINICAL BIOSTATISTICS - "Sample size calculation for stepped wedge cluster randomized trials with multiple levels of clustering"
2021-07-20 09:15 - 09:30 (America/New_York)
15:15-16:45 (9:15 am ET) Session OC4B: Cluster randomized trials

CHAIR: Andrew Copas

9:15 ET
Kendra Davis-Plourde, Monica Taljaard and Fan Li
Sample size calculation for stepped wedge cluster randomized trials with multiple levels of clustering

ABSTRACT. The stepped wedge cluster randomized trial is an attractive design for evaluating health services delivery or policy interventions. In this design, clusters start in the control condition and gradually cross over to the treatment based on a schedule dictated by random assignment. Outcomes may be assessed on the same individuals over time (i.e., a cohort design) or different individuals (i.e., a cross-sectional design). A key consideration in this design is that sample size calculation and analysis must account for within-period as well as between-period intracluster correlations; cohort designs have additional correlations due to repeated measures on the same individuals. While numerous methods have been developed to account for within- and between-period intracluster correlations with a single level of clustering during each time period, few methods are available to accommodate multiple levels of clustering. Our objectives were to develop computationally-efficient sample size procedures that recognize within-period and between-period intracluster correlations in stepped wedge trials with more than two levels of clustering. Focusing on three levels of clustering and assuming equal cluster-period sizes, we consider three variants, depending on whether each level is treated as a cross-sectional or closed-cohort design. We introduce an extended block exchangeable matrix to characterize the correlation structures both within- and between-clusters in each cluster-period and develop convenient sample size expressions that depend on this correlation structure. With a continuous outcome, we show the sample size expression depends on the correlation structure only through two eigenvalues of the extended block exchangeable matrix. For binary outcomes under a mixed effects framework, we develop a sample size expression based on a first-order Taylor approximation. We conduct simulation studies to examine the finite-sample properties of the proposed sample size algorithms and demonstrate the application of the proposed methods using the Washington State Expedited Partner Therapy trial: a multilevel stepped wedge trial that randomized local health jurisdictions (level 4) consisting of clinics (level 3) and observed patients (level 2) with respect to their Chlamydia infection status (level 1).

More event details: http://www.iscb2021.info/en/pages/iscb-2021-home

Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in PCTs – What Can We Learn From Implementation Trials?
2021-07-16 13:00 - 14:00
The NIH Health Care Systems Research Collaboratory is launching a special workshop series on its popular Grand Rounds program to explore the inclusion of diverse participants in pragmatic clinical trials. This series will include topics on increasing engagement of diverse participants and building trust, including diverse sites, learning from implementation science to maximize diversity, and developing a pipeline of trainees from underrepresented groups to be leaders in pragmatic clinical research.
Guest Moderator:
David Chambers, DPhil
Deputy Director for Implementation Science
Office of the Director in the Division of Cancer Control and Population Sciences (DCCPS)
National Cancer Institute (NCI)
National Institutes of Health (NIH)
Panel:
Amanda Midboe, PhD
Center for Innovation to Implementation
U.S. Department of Veterans Affairs
Chair of the Implementation Science Work Group for the NIH-DOD-VA Pain Management Collaboratory
Anne Trontell, MD, MPS
Associate Director
Clinical Effectiveness and Decision Science Program
Patient-Centered Outcomes Research Institute (PCORI)
Topic: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in PCTs – What Can We Learn From Implementation Trials?
Date: Friday, July 16, 2021, 1:00-2:00 p.m. ET
Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php.
To join the online meeting:
Go to https://dukemed.webex.com/dukemed/j.php?MTID=m228b52a4666c1e24046e11c01ae7bd0d

Virtual Forum: Artificial Intelligence/Machine Learning (AI/ML) Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD)
2021-06-25 13:00 - 16:00 | https://www.niddk.nih.gov/news/meetings-workshops/2021/artificial-intelligence-machine-learning-consortium
The Artificial Intelligence/Machine Learning (AI/ML) Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) virtual forum will occur on Friday, June 25th (1:00-4:00 PM EDT). This virtual forum aims to bring together stakeholders across academia, federal agencies, the data science/tech industry, and health care systems and centers who are interested in leveraging artificial intelligence and machine learning (AI/ML) for research, with a primary focus on mitigating health disparities. The purpose of this meeting will be to provide an overview of the initiative approved for funding by NIH and then engage attendees in listening sessions via breakout groups which will focused on three main topics: research interests, computing infrastructure and resources, and training needs. The meeting will conclude with a report back from these smaller breakout discussions and a final summary of the forum discussion and anticipated next steps. The feedback from this event will inform the establishment of mutually beneficial and coordinated partnerships to increase the participation and representation of researchers and communities currently underrepresented in the development of AI/ML models and enhance the capabilities of this emerging technology, beginning with EHR data.

Registration Closed: Due to the enthusiastic response, the AIM-AHEAD Team have reached the participation limit to ensure meaningful conversation, so they have closed registration. Over the next several weeks, they will have additional opportunities for people to provide feedback and ask questions, including a formal Request for Information (RFI) to gather written comments. They will also post a meeting summary of this stakeholder forum. If you have any questions about this event, please contact AIM-AHEAD@od.nih.gov.

Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity
2021-06-25 13:00 - 14:00
Guest Moderator:
Emily O’Brien, PhD
Associate Professor, Department of Population Health Sciences
Duke Clinical Research Institute
Duke University School of Medicine
Panel:
Jonathan Jackson, PhD
Executive Director
Community Access, Recruitment, and Engagement (CARE) Research Center
Massachusetts General Hospital and Harvard Medical School
Judith Schlaeger, PhD, CNM, LAc, FAAN
Associate Professor, Department of Human Development Nursing Science
University of Illinois Chicago
Stacy Sterling, DrPH, MSW, MPH
Research Scientist
Kaiser Permanente Division of Research, Northern California
Topic: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity
Date: Friday, June 25, 2021, 1:00-2:00 p.m. ET
Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php.
To join the online meeting:
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Pilot Grant Cycle 3A Full Proposals Due @5pm
2021-06-18 17:00
Pilot Grant Cycle 3A Full Proposals Due @5pm. There is a competitive two-step application process for which the required letter of intent (LOI) was due 3/5. Learn more at here: https://impactcollaboratory.org/pilot-grants-program/.

Grand Rounds: Debra Saliba, MD, MPH, and Joan Teno, MD, MS, to present on “Promises and Pitfalls of Existing Data in Nursing Homes”
2021-06-17 12:00 - 13:00
Join us for IMPACT Grand Rounds on Thursday, June 17, 2021 from 12-1pm ET as IMPACT Patient and Caregiver Relevant Outcomes (PCRO) Core Executive Committee Members Debra Saliba, MD, MPH, Anna and Harry Borun Endowed Chair in Geriatrics and Gerontology at UCLA, and Joan M. Teno, MD, MS, Professor of Medicine, Oregon Health & Science University, present on “Promises and Pitfalls of Existing Data in Nursing Homes.”
Thursday, June 17, 2021
12:00 – 1:00 pm ET
ZOOM Details:
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/97344810673
Dial-In: +1 312 626 6799 (US Toll) or +1 470 250 9358 (US Toll)
Meeting ID: 973 4481 0673

Inclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity
2021-06-04 13:00 - 14:00
The NIH Health Care Systems Research Collaboratory is launching a special workshop series on its popular Grand Rounds program to explore the inclusion of diverse participants in pragmatic clinical trials. This series will include topics on increasing engagement of diverse participants and building trust, including diverse sites, learning from implementation science to maximize diversity, and developing a pipeline of trainees from underrepresented groups to be leaders in pragmatic clinical research.
Guest Moderator:
Wendy Weber, ND, PhD, MPH
Chief, Clinical Research in Complementary and Integrative Health Branch
Division of Extramural Research
National Center for Complementary and Integrative Health (NCCIH)
National Institutes of Health (NIH)
Panel:
BeatPain Utah
Julie Fritz, PhD, PT
Associate Dean for Research, College of Health
Adjunct Professor, Orthopaedic Surgery
Distinguished Professor, Physical Therapy & Athletic Training
Adjunct Professor, Orthopaedic Surgery Operations
University of Utah
David Wetter, PhD, MS
Professor, Population Health Sciences
Adjunct Professor, Psychology
University of Utah
STOP CRC
Gloria Coronado, PhD
Distinguished Investigator
Mitch Greenlick Endowed Scientist for Health Disparities
Kaiser Permanente Center for Health Research
Amanda Petrik, MS
Sr. Research Associate
Center for Health Research
Kaiser Permanente Northwest
Topic: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity
Date: Friday, June 4, 2021, 1:00-2:00 p.m. ET
Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php.
To join the online meeting:
Go to https://dukemed.webex.com/dukemed/j.php?MTID=m228b52a4666c1e24046e11c01ae7bd0d

ISAC/Brown Clinical Trials Seminar - "IMPACT-C: Improving Vaccine Uptake in Skilled Nursing Facilities" - Sarah Berry, MD, MPH
2021-05-27 12:00 - 13:00
Please join us for a lecture from the Joint Seminar Series on Clinical Trials in Aging: Strategies to Improve Nursing Home COVID-19
Vaccine Uptake featuring Sarah Berry, MD, MPH, Harvard Medical School & Hinda and Arthur Marcus Institute for Aging Research.
Nursing homes residents represent about 1% of the US population but, at the height of the pandemic, contributed about 5% of cases and nearly 40% of deaths. Residents and staff were prioritized for vaccination, but staff uptake, in particular, has remained low.
Dr. Berry will present on strategies to improve COVID-19 vaccine uptake, including data from IMPACT Collaboratory observational studies and a pragmatic trial.
The Joint Seminar Series on Clinical Trials in Aging is co-hosted by the Interventional Studies in Aging Center (ISAC) in the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife and the Brown University Center for Long-Term Care Quality & Innovation (Q&I). Lectures focus on issues in the design and execution of clinical trials, including trials currently in the field.
Thursday, May 27, 2021
12:00 – 1:00 pm ET
Zoom Details:
Join from PC, Mac, Linux, iOS or Android: https://hebrewseniorlife.zoom.us/j/89039784165
Or iPhone one-tap (US Toll): +14702509358,,89039784165# or +14703812552,,89039784165#
Dial-In: +1 470 250 9358 (US Toll) or +1 669 900 6833 (US Toll)
Meeting ID: 890 3978 4165

Webinar: Using the NIA Health Disparities Framework to Optimize Equity in Aging Research
2021-05-21 13:00 - 14:30
Duke Center for the Study of Aging and Human Development, REACH Equity, and Roybal Center will present “Using the NIA Health Disparities Framework to Optimize Equity in Aging Research” on May 21 from 1 to 2:30 p.m. EST. Registration closed.

Grand Rounds: Claire Chan, MSc, to present on "Pilot and Feasibility Studies for Pragmatic Cluster Randomised Trials"
2021-05-20 12:00 - 13:00
Join us for IMAPCT Grand Rounds on Thursday, May 20, 2021 from 12-1pm ET as Claire Chan, MSc, statistician with the Queen Mary University of London, presents on Pilot and Feasibility Studies for Pragmatic Cluster Randomised Trials.

Thursday, May 20, 2021
12:00 – 1:00 pm ET
ZOOM Details:
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/97344810673
Dial-In: +1 312 626 6799 (US Toll) or +1 470 250 9358 (US Toll)
Meeting ID: 973 4481 0673

NIH Collaboratory Grand Rounds Workshop Series: Inclusion of Diverse Participants in Pragmatic Clinical Trials
2021-05-14 13:00 - 14:00
The NIH Health Care Systems Research Collaboratory is launching a special workshop series on its popular Grand Rounds program to explore the inclusion of diverse participants in pragmatic clinical trials. This series will include topics on increasing engagement of diverse participants and building trust, including diverse sites, learning from implementation science to maximize diversity, and developing a pipeline of trainees from underrepresented groups to be leaders in pragmatic clinical research.
The webinar series will kick off on Friday, May 14, at 1 p.m. ET with a keynote presentation by Dr. Clyde Yancy, Vice Dean of Diversity and Inclusion and Chief of Cardiology in the Department of Medicine at Northwestern University Feinberg School of Medicine.

2021 AFTD Education Conference (Two Days)
2021-05-13 12:00 - 16:00
On May 13th and 14th, from 12 p.m. to 4 p.m. ET each day, the Association for Frontotemporal Degeneration (AFTD) will convene its 2021 Education Conference online. People and families affected by FTD will find help, support, and opportunities to connect. Researchers and experts will offer information and guidance through interactive presentations. Health professionals will find information and strategies they can use to better serve families.
Every year, AFTD brings together people and families navigating the FTD journey — as well as researchers and health professionals — to learn about the latest in FTD research, and to learn new strategies for care, management, and support. Our conference offers a chance to connect with others who understand — and share hope for a future free of FTD.
For the health and safety of all, this year’s conference will be broadcast online. It is free to attend.
Learn more on the AFTD website.

2021 Health Care Systems Research Network (HCSRN) Conference
2021-05-11 - 2021-05-12
The HCSRN annual conference is the nation’s preeminent gathering for researchers based in real-world health care systems and our numerous collaborators in academic health systems, funding agencies, and patient-partner communities. The conference offers a diverse slate of content, showcasing rigorous, relevant research on important conditions affecting millions of patients.
IMPACT members are among the panelists presenting, “Aging Research Opportunities for the HCSRN: Finally Reaching Maturity Chronic Conditions, Multi-Morbidity & Aging Populations” at 3:00 PM on Wednesday, May 12.
The National Institute of Aging (NIA) has invested in the development of infrastructure within the framework of aging research. This panel will provide an overview of three major NIA-funded initiatives that lead efforts to support aging research and training of junior investigators. The Health Care Systems Research Network (HCSRN)-Claude D. Pepper Older Americans Independence Centers (HCSRN-OAIC) “AGING” (Advancing Geriatrics Infrastructure & Network Growth) Initiative aims to create a national resource to nurture and advance an interdisciplinary research agenda focused on older adults with multiple chronic conditions. The National Institute on Aging (NIA) IMbedded Pragmatic Alzheimers disease (AD) and AD Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory aims to build the nation’s capacity to conduct pragmatic clinical trials of interventions embedded within health care systems for people living with dementia and their care partners. The US Deprescribing Research Network (USDeN) aims to develop and disseminate evidence about deprescribing for older adults, and in doing so to help improve medication use among older adults and the outcomes that are important to them.

Presenters:

Elizabeth Bayliss, Kaiser Permanente Colorado, CO
Jerry Gurwitz, Meyers Primary Care Institute, MA
Leah Hanson, HealthPartners, MN
Eric Larson, Kaiser Permanente Washington, MA
Marcel Salive, NIA, MD

Advancing Research on Care and Outcome Measurements (ARCOM) funding program Letters of Intent due
2021-05-05
In collaboration with LINC-AD (Leveraging an Interdisciplinary Consortium to Improve Care and Outcomes for Persons Living with Alzheimer’s and Dementia), the Alzheimer’s Association is currently accepting applications for the new Advancing Research on Care and Outcome Measurements (ARCOM) funding program. The goal of the program is to address gaps in care and outcome measurement and advance research efforts to ensure that care providers are implementing evidence-based practices (using measures to guide care provision) and achieving desired outcomes (using measures to assess outcomes). Work funded through ARCOM must directly advance research projects focused on development of new and/or validation of previously developed measures of care and outcomes where measurement gaps exist.
The Alzheimer’s Association anticipates funding up to 8 ACROM proposals for up to $250,000 total funding (direct and indirect costs) over a period of up to two years (minimum of 1 year).
Read the full RFA here. A letter of intent is due by May 5.
To learn more about this funding opportunity, visit their website.

Demonstration Project Proposals Due @ 5pm
2021-04-30 17:00
Demonstration Project Proposals due at 5pm on April 30, 2021. Learn more here: https://impactcollaboratory.org/demonstration-grants-program/.

NIA Virtual Meeting: Development of an NIA Practice-Based Research Network to Conduct AD/ADRD Clinical Research
2021-04-30 14:00 - 17:00
The AGING Initiative is pleased to share an upcoming virtual meeting opportunity on behalf of the National Institute on Aging (NIA):
The NIA will be hosting a virtual meeting on Friday, April 30 from 2:00–5:00pm EST on the “Development of an NIA Practice-Based Research Network to Conduct Alzheimer’s and Related Dementias Clinical Research.”
The meeting will discuss the potential and planning of a practice-based research network (PBRN) to address the disparities gap with the recruitment and retention of diverse and underserved populations to AD/ADRD clinical research studies. PBRNs are networks of health care clinicians and practices working together to answer community-based health care questions and translate research findings into practice—they have the potential to directly engage diverse and underserved communities in AD/ADRD clinical research.
Registration closed.
Keynote Speakers

Lori Minasian, MD
Jonathan N. Tobin, PhD

Panel Speakers

Jennifer Manly, PhD
Andrea Gilmore-Bykovskyi, PhD, RN
Jonathan Jackson, PhD
Vince Mor, PhD

The CDC Nursing Home COVID-19 Immunization Initiative: An Amazing Success Story
2021-04-15 14:00 - 15:00
The AGING Initiative, AGS, and RCCN are co-hosting an upcoming webinar. IMPACT’s Leah Hanson, PhD will be providing introductions. The webinar will be presented by Ruth Link-Gelles, PhD, Staff Epidemiologist for the CDC and Lieutenant Commander for the US Public Health Service Commissioned Corps. Dr. Link-Gelles will be discussing the massive effort and success story of the CDC in immunizing nursing home and long-term care facility residents against COVID-19 following vaccine approval in the United States.
Registration closed.

Grand Rounds: Consuelo H. Wilkins, MD, MSCI to present on "Inclusion, diversity, and equity in pragmatic clinical trials"
2021-04-15 12:00 - 13:00 | https://hebrewseniorlife.zoom.us/j/97344810673
Join us for IMAPCT Grand Rounds on Thursday, April 15, 2021 from 12-1pm ET as Consuelo Wilkins, MD, MSCI presents on “Inclusion, diversity, and equity in pragmatic clinical trials.”
Consuelo H. Wilkins, MD, MSCI
Vice President for Health Equity, VUMC
Associate Dean for Health Equity, Vanderbilt SOM
Professor of Medicine, Division of Geriatric Medicine
Thursday, April 15, 2021
12:00 – 1:00 pm ET
ZOOM Details:
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/97344810673
Dial-In: +1 312 626 6799 (US Toll) or +1 470 250 9358 (US Toll)
Meeting ID: 973 4481 0673

Breaking the Silence: Addressing Dementia in Communities of Color
2021-04-15 10:30 - 12:30
Jonathan Jackson, PhD, member of the Executive Committee of the IMPACT Health Equity team will be the keynote speaker for this virtual event.
April marks National Minority Health Month – highlighting health disparities that persist among racial and ethnic minority populations and the ways in which legislation, policies, and programs can help advance health equity. Through this annual event, it is our hope that individuals and families will feel empowered, receive information surrounding the health of communities of color, and share their knowledge with others to take charge of their health. Together, we can keep the momentum going and continue to BREAK THE SILENCE in communities of color; helping individuals and families get access to the services they need.
Registration closed.
This is a virtual event. Please RSVP by April 14, 2021. To register by phone, contact Gail Morgan at (414) 219-5124. After you register, event login instructions will be emailed to you.
Theme: Meet the People Where They Are: Continuing the Dialogue on Inclusivity in Research
Keynote Speaker:
Jonathan D. Jackson, PhD, is the founder and Executive Director of the Community Access, Recruitment, & Engagement (CARE) Research Center at Massachusetts General Hospital and an Instructor in Neurology at Harvard Medical School. His research focuses on midlife and late-life health disparities in clinical settings that affect Black populations. Dr. Jackson serves on Mass General’s Alzheimer’s Disease Research Center (ADRC) and Mass General’s Cancer Center Equity Program, specializing in identifying and overcoming barriers to clinical research for people and communities of color and on statewide and national advisory groups for research recruitment, Alzheimer’s disease and community engagement.

Application Deadline 4/8/21: NIH funded Alzheimer's Association Interdisciplinary Summer Institute (AA-ISRI)
2021-04-08
The Summer Institute is an immersive, no-cost opportunity for early career researchers in psychosocial care and public health to launch a career in dementia science and accelerate breakthroughs in the field. I’m helping to organize it along with Julie Bynum, Matthew Baumgart, Carl Hill, and Sam Fazio as the lead. Several IMPACT members are serving as faculty.
The AA-ISRI will be held in Chicago, August 9-13, 2021, where experts will offer diverse perspectives on ground-breaking research through group sessions and individual mentoring. Applications are due April 8, 2021. Twenty-four applicants will be selected for this exclusive experience.
Please visit the website to learn about the AA-ISRI schedule, faculty and more.
https://www.alz.org/summer-research-institute/overview.asp

Annual IMPACT Training Workshop & Retreat
2021-04-07 - 2021-04-08
The IMPACT Collaboratory will hold its first annual Training Workshop and Retreat, “Building Skills to Conduct Embedded Pragmatic Clinical Trials for People Living with Dementia (PLWD) and their Care Partners,” on April 7-8, 2021.
We are inviting applications from early to mid-career researchers who seek to develop competence in designing and conducting ePCTs of interventions to improve care for PWLD and their care partners. We anticipate accepting up to 25 participants to attend the workshop.
This virtual 1.5-day workshop and retreat will provide a foundation in practical aspects of designing and conducting ePCTs in AD/ADRD through a combination of panel discussions, small group sessions, and networking opportunities with experts in the field. Workshop modules will focus on healthcare systems, implementation science, and study design.
Participants will gain knowledge in ePCT design and method, problem-solve challenges faced in current or planned projects, and network and engage with the larger community of IMPACT investigators. Throughout the program, special attention will be paid to key considerations in design, implementation, and monitoring ePCTs of PLWD and care partners to ensure health equity.
Successful applicants will be expected to complete selected readings and online training prior to the workshop. Please note that all participants will be expected to attend and participate in the entire 1.5-day IMPACT Collaboratory Training Workshop and Retreat.
Please help to publicize this training program and encourage your investigators and colleagues to apply.
EVENT DETAILS (virtual):<
Wednesday, April 7, 2021 from 1:30pm – 4:30pm ET
Thursday, April 8, 2021 from 10:00am – 4:30pm ET
TO APPLY:
For more information and to apply please visit: https://impactcollaboratory.org/training-workshop

Deadline: Friday, January 15, 2021
Application: Closed January 15, 2021.

ELIGIBILITY CRITERIA: Applicants should have an MD, PhD, or equivalent research degree and hold a full-time position at an academic or research organization in the United States. Although the primary audience is early-career investigators, mid-career applicants who are seeking to change their career path to pursue research on ePCTs in AD/ADRD will be considered. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are encouraged to apply.
SELECTION CRITERIA: Applicants will be selected based on their demonstrated commitment to improving the care of people living with dementia and/or their caregivers through the conduct of ePCTs in health care systems and the potential impact of the workshop on promoting the applicant’s career in this area.
If you have any questions regarding this opportunity, please email IMPACTcollaboratory@hsl.harvard.edu

NIA IMPACT Steering Committee & Business Planning Meeting Year 2 Livestream
2021-04-06 10:30 - 11:30
Join us for a one-hour livestream of our annual Steering Committee & Business Planning Meeting at this link: https://bit.ly/3dx96jo
Agenda
10:30 am
Welcome
Vince Mor, PhD, Brown University
Susan Mitchell, MD, MPH, Marcus Institute for Aging Research, Hebrew SeniorLife
10:40 am
Remarks from the National Institute on Aging Richard Hodes, MD, Director, National Institute on Aging
10:50 am
Mission Moment – Reflection on Living with Dementia in the Context of COVID
Brenda Nicholson, MD, Retired Physician, Person Living with Dementia
11:00 am
General Overview of Collaboratory & Milestones Susan Mitchell, MD, MPH, Marcus Institute for Aging Research, Hebrew SeniorLife Vince Mor, PhD, Brown University

Annual IMPACT Collaboratory Steering Committee & Business Planning Meeting
2021-04-06 - 2021-04-07
Each year, the IMPACT Collaboratory holds an internal Steering Committee and Business Planning Meeting with all IMPACT Collaboratory Members. These are usually held in-person in Bethesda, MD, but this our 2021 meeting will be virtual.

Career Development Award Proposals Due @ 5pm
2021-04-02 08:00 - 17:00
Program Overview and Rationale
The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) was established in 2019 to build the nation’s capacity to conduct embedded pragmatic clinical trials of non-pharmacologic interventions within healthcare systems (HCS) to improve the care of people living with AD/ADRD and their care partners.
Conducting ePCTs in AD/ADRD within HCS requires unique research skills, yet the field is relatively nascent. The number of investigators capable of rigorously designing and executing ePCTs in partnership with HCS and other key stakeholders remains limited, and those that have intersecting expertise in AD/ADRD populations are even fewer. Thus, a critical objective of the IMPACT Collaboratory is to build the nation’s capacity to conduct impactful ePCTs in AD/ADRD by training a workforce of investigators prepared to carry on this work well into the future.
Funding Opportunity Description
The IMPACT Collaboratory funds up to four career development awards (CDAs) annually. These CDAs seek to support the development of early-stage MD, PhD, or equivalent researchers who seek careers conducting ePCTs for people living with AD/ADRD and their care partners. The IMPACT Collaboratory prioritizes applications that address dementia care for people of all backgrounds and promote health equity.
CDA applicants must:

Be no more than 7 years out of their post-doctoral training program at the time of application. With prior approval, rare exceptions may be made for investigators more than 7 years from postdoctoral training who are seeking to change their career path to pursue research on ePCTs among PLWD.
Demonstrate a commitment to pursuing a career in conducting ePCTs for PLWD and their care partners. This is best demonstrated by current or prior training, clinical work, publications, or research projects focused on improving care for PLWD and their care partners.
Demonstrate basic training (post-graduate) in fundamental clinical research methods and have completed training in the ethical conduct of clinical research.
Provide evidence of prior research productivity in seeking to improve ou tcomes of PLWD.
Identify a mentoring team that includes expertise in: (a) conducting ePCTs for PLWD and their care partners; (b) organizational change within healthcare systems; and (c) professional development of clinical researchers.
Describe a two-year training plan in collaboration with their mentoring team focused on training in the conduct of ePCTs for PLWD and their care partners.
Propose a research project focused on: (a) building competency and experience in ePCTs among PLWD; and (b) generating preliminary, publishable data that will build a foundation for ongoing research focusing on ePCTs for PLWD. Projects may employ a variety of research methods, such as primary or secondary data analysis, intervention development, outcome measure development, feasibility of implementation, pilot ePCTs, or qualitative methods.
Exceptional candidates with also demonstrate access to, and collaboration with, organizational leadership within a targeted HCS. This may be demonstrated by a current or planned relationship with health system leadership at the site where the research will be conducted or other evidence of engagement with heath system leadership.
Attend the annual 2-day IMPACT Collaboratory national Training Workshop and Retreat with your mentor in both years of the CDA, which will be held in scheduled for April 2022. When available, these dates can be found at https://impactcollaboratory.org/cda/.
Participate in quarterly mentoring meetings with one or more representatives from the IMPACT Collaboratory Core Groups and Teams in addition to regular meetings with their local mentor(s).

Read full details on the Career Development Award Program here: https://impactcollaboratory.org/cda/

IMPACT Grand Rounds: Updates from Two IMPACT Pilot Studies
2021-03-18 12:00 - 13:00 | https://hebrewseniorlife.zoom.us/j/97344810673
Join us at our monthly Grand Rounds on Thursday, March 18, 2021 @ 12:00 – 1:00 pm ET for an update from two IMPACT Pilot Studies:
Brent Forester, MD, MSc
Implementation of the Care Ecosystem training model for individuals with dementia in a high risk, integrated care management program
Ula Hwang, MD, MPH
Pathway to Detection & Differentiation of Delirium & Dementia in the Emergency Department
Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/97344810673
Dial-In: +1 312 626 6799 (US Toll) or +1 470 250 9358 (US Toll); Meeting ID: 973 4481 0673

Pragmatic Trials in Long-Term Care: A Consensus Conference
2021-03-10 09:00 - 16:00 | https://www.eventscribe.net/2021/PALTC21/aaStatic.asp?SFP=WUtSUUxCQk1ANjQ2Nw
Virtually | March 10, 2021 | 9:00 AM – 4:00 PM EST | funded by the National Institute of Aging and led by editors of three leading geriatrics journals — JAMDA (The Journal of Post-Acute and Long-Term Care Medicine), JAGS (The Journal of the American Geriatrics Society), and Geriatric Nursing – will identify priorities and best practices for pragmatic trials in long-term care, with a focus on care for persons with dementia.
Experts across the globe agree that we are at a tipping point to improve systems of long-term care for older adults; they also agree that pragmatic trials are the most promising strategy toward that end. However, the focus of such trials, the best methods with which to conduct them, how best to share results, and how best to promote uptake of evidence-proven practices, are far from clear.
Speakers include internationally renowned research experts, directors of national long-term care organizations, and leaders of national associations and societies. IMPACT Member Participants include Joe Gaugler, PhD, David Gifford, MD, MPH, Laura Hanson, MD, MPH, Vince Mor, PhD, Kathleen Unroe, MD, MHA, Sheryl Zimmerman, PhD.
Target Audience: This conference is intended for providers, researchers, and policy makers who aim to promote better care in nursing homes, assisted living communities, and other residential settings that serve older adults.
For more details and registration, visit: https://www.eventscribe.net/2021/PALTC21/aaStatic.asp?SFP=WUtSUUxCQk1ANjQ2Nw

Pilot Grant Cycle 3A Informational Webinar 2
2021-02-22 16:00 - 17:00
The second of two optional informational webinars to provide investigators with an overview of application details and support that the IMPACT Collaboratory can provide in assistance with proposal development (e.g., trial design, measurement, data extraction, etc.). Investigators will have the opportunity to ask questions. Pre-registration is required using the links below.

Monday, February 22, 2021 at 4:00 pm ET: Registration closed.

Click here for full details on Pilot Grant Cycle 3A.

IMPACT Grand Rounds: Stuart Nicholls, PhD presents on "Ethical challenges with pragmatic RCTs: General issues and special considerations in dementia"
2021-02-18 12:00 - 13:00 | https://hebrewseniorlife.zoom.us/j/97344810673
Stuart G. Nicholls, PhD
Senior Clinical Research Associate & Strategy for Patient Oriented Research (SPOR) Facilitator,
Clinical Epidemiology Program,
Ottawa Hospital Research Institute
Thursday, February 18, 2021
12:00 – 1:00 pm EST
Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/97344810673
Dial-In: +1 312 626 6799 (US Toll) or +1 470 250 9358 (US Toll)
Meeting ID: 973 4481 0673

Demonstration Projects Program Informational Webinar
2021-02-11 14:00 - 15:00
An optional informational webinar to provide investigators and their operational or clinical partners with an overview of application details and support that the IMPACT Collaboratory can provide in assistance with proposal development (e.g., trial design, measurement, data extraction, etc.). Individuals will have the opportunity to ask questions. Pre-registration is required using the link below:

Thursday, February 11, 2021 at 2:00 pm ET. Registration closed.

Click here for full information about the IMPACT Demonstration Projects.

HCS Scholars Informational Webinar
2021-02-11 13:00 - 14:00
An optional informational webinar about the program hosted by the Health Care Systems Core to provide investigators with an overview of program and application details. Investigators will have the opportunity to ask questions. Pre-registration is required using the link below.

Thursday, February 11, 2021 at 1:00 pm ET: Registration closed.

Click here for full information about the Health Care Scholars Program.
