NIA IMPACT Collaboratory

Career Development Awards Informational Webinar #1
2020-04-29 15:00 - 16:00 (America/New_York)
The IMPACT Collaboratory will fund two to three, 2-year Career Development Awards (CDAs) to support the development of early-stage MD, PhD, or equivalent researchers who seek careers conducting embedded pragmatic clinical trials (ePCTs) for people living with dementia and their care partners. CDAs provide support for up to $100,000 per year in direct costs and candidates are required to devote a minimum of 75% effort toward the goals of the CDA. The IMPACT Collaboratory will prioritize applications that address dementia care for people of all backgrounds and promote health equity.
Full Applications are due July 15, 2020. There is no letter of intent. For further details, go to the IMPACT CDA Program webpage.
Two optional informational webinars will be held to provide additional information and answer questions from potential applicants. Registration is required and can be completed through the links below:
• Informational Webinar #1 for IMPACT CDA April 29, 2020 03:00 PM Eastern Time. Registration closed.

Pilot Grants Program Informational Webinar #1
2020-04-28 13:30 - 14:30
The IMPACT Collaboratory will fund up to five 1-year non-renewable pilot grant awards for up to $175,000 in direct costs. Letters of intent are required and due May 29, 2020. Full proposal applications are by invitation only and will be due September 4, 2020. For further details, please see the on the IMPACT Pilot Grant Program page.
In response to the coronavirus disease (COVID-2019) outbreak, the IMPACT Collaboratory will prioritize applications proposing pilot ePCTs of telemedicine, telehealth, and remote technologies interventions aimed at improving health care, unmet needs, quality of life and/or health outcomes for people living with dementia and/or their care partners for this award cycle. Applications for pilot ePCTs testing other types of non-pharmacological interventions in this population will also be considered.
Informational Webinar #1 for IMPACT Pilot Grant RFA is April 28, 2020 01:30 PM Eastern Time. Registration closed.

Palliative Care Research and COVID-19
2020-04-21 12:00 - 13:00
The Palliative Care Research Cooperative (PCRC) Group IDC Webinar Series will feature a presentation on Palliative Care Research and COVID-19 presented by Ashwin Kotwal, MD, MS and Alex Smith, MD, MPH.
Event Details:
April 21 @12:00-1:00 pm ET
Registration closed.

IMPACT Grand Rounds: Health equity as foundational to the design of pragmatic clinical trials
2020-04-16 12:00 - 13:00
Thursday, April 16, 2020
12:00 – 1:00 pm ET
Ana Quiñones, PhD, MS
Associate Professor, Department of Family Medicine,
OHSU-PSU School of Public Health, Oregon Health & Science University

Jonathan Jackson, PhD
Instructor in Neurology, Massachusetts General Hospital
Instructor, Harvard Medical School

Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/5479652617
Dial-In: +1 646 876 9923 (US Toll) or +1 669 900 6833 (US Toll)
Meeting ID: 547 965 2617
Download the event flyer

Care Interventions for Individuals with Dementia and Their Caregivers: A Virtual Workshop
2020-04-15 10:00 - 17:00
National Academies of Sciences, Engineering, and Medicine will be hosting “Care Interventions for Individuals with Dementia and Their Caregivers: A Virtual Workshop” that will bring together key stakeholders and experts to provide input to the committee on a draft Agency for Healthcare Research and Quality (AHRQ) systematic review that examines existing evidence on care interventions that support individuals with dementia and their caregivers. This AHRQ systematic review will form the predominant basis of the National Academies committee’s report on which care interventions can be considered ready for broad implementation and dissemination.
Event Date: Wednesday, April 15, 2020 from 10am-5pm ET.
Event details.
Registration closed.

Living Textbook Grand Rounds Series March 27: Part 3-Tips for Putting Together a Successful PCT Grant Application
2020-03-27 12:00 - 13:00
Speaker:

Wendy Weber, ND, PhD, MPH
Branch Chief, Clinical Research Branch
Division of Extramural Research, NCCIH
For all Grand Round details, go to: https://rethinkingclinicaltrials.org/event/living-textbook-grand-rounds-series-march-27-part-3-secrets-to-getting-your-pragmatic-trial-funded/

PCRC Investigator Development Center webinar series highlight
2020-03-10 13:00 - 14:00
March 10, 2020
1:00pm-2:00pm Eastern time
Ab Brody, PhD, RN, FAAN, leader of the IMPACT Pilot Studies Core, will be presenting “Conducting Palliative Care Trials with Persons Living with Dementia and their Caregivers: Key Decisions for Developing a Successful Trial” in PCRC’s Investigator Development Center (IDC) webinar series.
Learn more by clicking here: https://palliativecareresearch.org/research/investigator-support-information/idc-webinar-series
Registration closed.

Grand Rounds: Modifications and waivers of informed consent in pragmatic clinical trials
2020-02-20 12:00 - 13:00
Jason Karlawish, MD
Professor of Medicine, Medical Ethics and Health Policy, and Neurology
Co-Director, Penn Memory Center, University of Pennsylvania
Thursday, February 20, 2020
12:00 – 1:00 pm EST

Jason Karlawish, MD is a professor of medicine, medical ethics and health policy, and neurology at Penn and cares for patients at the Penn Memory Center, which he co-directs. His research focuses on issues at the intersections of bioethics, aging and the neurosciences. He leads the Penn Program for Precision Medicine for the Brain (P3MB). P3MB developed standards for Alzheimer’s disease biomarker disclosure and investigates the clinical impacts of this knowledge on persons and their families. He has investigated the psychological and ethical implications of biomarker-based Alzheimer’s disease diagnostics and treatments, informed consent, quality of life, research and treatment decision making, stigma and voting by persons with cognitive impairment and residents of long term care facilities.

Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/5479652617
Dial-In: +1 646 876 9923 (US Toll) or +1 669 900 6833 (US Toll)
Meeting ID: 547 965 2617

Steering Committee and Business Planning: Year 1 Meeting 1
2020-01-28 - 2020-01-29
Members of the NIA IMPACT Collaboratory Steering Committee will gather to discuss the project and plan for the upcoming year.
Location: Bethesda, MD

Grand Rounds: Using a Pilot to Test and Refine Your Measurement Strategy
2020-01-23 12:00 - 13:00
A hallmark of embedded pragmatic trials (ePCTs) is use of existing data sources to evaluate study outcomes. In ePCTs focused on people with dementia, behavioral outcomes of interest are often under-documented in the existing administrative data. Using a case example, we describe how a pilot can be used to test the adequacy of existing data for evaluating your ePCT outcome. We also describe a potentially efficient ePCT design that accommodates under-detection in existing data while maintaining large-scale implementation and evaluation.
Speaker
Ellen McCreedy, PhD, MPH
Assistant Professor, Center for Gerontology and Healthcare Research, Brown University School of Public Health
Ellen McCreedy, PhD, MPH is interested in improving the quality of life for people living with advanced dementia. Her research goals are to reduce the amount of futile and burdensome care received at the end of life; and to provide comfort, meaning, and moments of joy to people living with dementia and their families. Professor McCreedy received her MPH in Global Health from the University of South Florida, her PhD in Health Services Research from the University of Minnesota, and recently completed a postdoctoral research fellowship at Brown University, Center for Gerontology and Healthcare Research. Dr. McCreedy is directing a pragmatic trial of a personalized music intervention to reduce agitation and isolation in nursing home residents living with dementia.
Learning Objectives

Describe how a pilot study can be used to test the adequacy of existing data sources for the purposes of evaluating your ePCT.
Give three reasons why existing administrative data may suffer from under-detection of behaviors in persons with dementia.
Discuss an alternative ePCT design that addresses potential under-detection in existing administrative data sources.

Date & Time
Thursday, January 23, 2020
12:00 – 1:00 pm EST

How to Join
Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/5479652617
Dial-In: +1 646 876 9923 (US Toll) or +1 669 900 6833 (US Toll)
Meeting ID: 547 965 2617
Keywords
Administrative data, dementia-related behaviors, measurement, piloting
Additional Resources
McCreedy EM, Yang X, Baier RR, Rudolph JL, Thomas KS, Mor V. Measuring effects of nondrug interventions on behaviors: music & memory pilot study. Journal of the American Geriatrics Society. 2019 Oct;67(10):2134-8.

Grand Rounds
2019-12-19 12:00 - 13:00 | NC, United States
Stepped wedge cluster trials: What, how, and when?
Monica Taljaard, PhD
Senior Scientist, Ottawa Hospital Research Institute
Associate Professor, University of Ottawa
Thursday, December 19, 2019
12:00 – 1:00 pm EST
Learning Objectives:

Describe the key characteristics and main types of stepped wedge cluster randomized trials (SW-CRTs) with examples.
Explain the main approach to analysis and sample size calculation for SW-CRTs.
Discuss what is an appropriate justification for using a SW-CRTs.

Monica Taljaard, PhD is a biostatistician specializing in the design, analysis, and ethics of pragmatic cluster randomized and stepped wedge trials. As a member of the Ottawa Hospital Research Institute (OHRI) Methods Center, she regularly provides biostatistical assistance to investigators in the design, conduct, and analysis of pragmatic trials, pilot trials, quality improvement interventions, and health system projects. Since Dr. Taljaard’s academic appointment in 2006, she has published over 240 peer-reviewed manuscripts and has received over $10M in peer-reviewed research grants as principal investigator from the Canadian Institutes of Health Research, in addition to $110 million in peer-reviewed research funding as co-investigator. She has collaborated with investigators in the design and analysis of a large-scale pragmatic cluster randomized trials in US Nursing homes, and studies in palliative and end-of-life care, dementia, long-term care, perioperative care of the frail elderly, and health care system quality improvement in nursing homes.
Zoom Conferencing
Join from PC, Mac, iOS or Android: https://hebrewseniorlife.zoom.us/j/5479652617
Dial-In: +1 646 876 9923 (US Toll) or +1 669 900 6833 (US Toll)
Meeting ID: 547 965 2617

Grand Rounds Webinar: Are You Ready for a Pragmatic Trial? The RAPT Model and Implementation Considerations
2019-11-21 12:00 - 13:00
This webinar will describe the use of the Readiness Assessment for Pragmatic Trials (RAPT) model to asses an intervention’s readiness for a pragmatic randomized, controlled trial (PCT). PCTs are gaining momentum among among interventionists and funding agencies seeking to accelerate the testing and adoption of evidence-based strategies to improve care and outcomes because their findings are generalizable. Particular attention is being paid to non-pharmacological interventions, which are often complex and may be difficult to uniformly implement across multiple sites. While many such non-pharmacological interventions have proven efficacious in small trials, most have not been widely adopted. PCTs could accelerate effectiveness testing and adoption, yet there are no established criteria to identify interventions ready for testing in a PCT. This webinar will help demonstrate how the RAPT model can help to establish those criteria.
Read more about the RAPT Model

Download the event flyer
