The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is happy to announce a Request for Applications for two separate funding opportunities: Pilot Grant Program and Demonstration Projects Program.  These opportunities support research and training to increase the nation’s capacity to conduct pragmatic clinical trials (ePCTs) of non-pharmacological interventions within healthcare systems to improve care for people living with Alzheimer’s disease (AD) and AD-related dementias(AD/ADRD) and their care partners.

Two NIA IMPACT Funding Opportunities

Pilot Grants Program
IMPACT will fund up to five 1-year awards for pilot pragmatic clinical trials (ePCTs) that test non-pharmacological interventions embedded in health care system(s) for people living with Alzheimer’s Disease (AD) and AD-related dementias (ADRD) and their care partners.  The goal of these pilot studies is to generate the preliminary data necessary to design and conduct a future full-scale Stage IV effectiveness ePCT (based on the NIH Stage Model) funded through other grant mechanisms.

This grant cycle will prioritize applications for non-pharmacological interventions that aim to:

• Reduce inequities in health care
• Reduce potentially inappropriate medications through de-prescribing
• Improve care in the emergency department

Learn more about previous Pilot Grant Awardees here.  If you have questions about the Pilot Grant Program please visit the Frequently Asked Questions webpage or email IMPACTcollaboratory@hsl.harvard.edu.

Demonstration Projects Program

IMPACT will fund up to two 18-month Demonstration Projects designed as full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that test, measure and evaluate the effect of a care delivery intervention program in health care systems for people living with AD/ADRD and their care partners. The goal of these Demonstration Projects is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems.

Under this mechanism, the interventions must be linked to the needs of the health care system. Suitable intervention typically encompass relatively simple system changes or direct patient outreach, or successfully piloted programs ready for testing at scale. Demonstration Projects allow health care systems and investigators to gain real-world experience integrating pragmatic non-pharmacological interventions into usual clinical workflow and health care delivery practices in a controlled manner that provides clear information on the impact of the intervention program.

Learn more about previous Demonstration Project Awardees here. If you have questions about the Demonstration Project Program, please visit the Frequently Asked Questions webpage or email IMPACTcollaboratory@hsl.harvard.edu.

Learn more about the IMPACT Collaboratory on our website. Keep up-to-date on these and future opportunities by joining our mailing list and following us on social media at IMPACT Twitter IMPACT LinkedIn.

Please help to publicize the IMPACT funding and training opportunities and encourage investigators and colleagues to apply.