December 9, 2022
Monica Taljaard, PhD, member of the executive committee of the IMPACT Design & Statistics Core is among authors who published an article describing how and why pragmatic trials underachieved or overachieved their target sample sizes.
Abstract
Objectives: To describe the extent to which pragmatic trials underachieved or overachieved their target sample sizes, examine explanations and identify characteristics associated with under-recruitment and over-recruitment.
Study design and setting: Secondary analysis of an existing database of primary trial reports published during 2014-2019, registered in ClinicalTrials.gov, self-labelled as pragmatic and with target and achieved sample sizes available.