Review of pragmatic trials finds multiple primary outcomes are common but also identifies need for improved transparency in co-primary outcomes

Posted on by Sonya Sutton

Review of pragmatic trials found that multiple primary outcomes are common but so too are discrepancies between protocols and final reports

December 8, 2021

Monica Taljaard, PhD, member of the executive committee of the IMPACT Design & Statistics Core, has co-authored a publication describing the prevalence of multiple primary outcomes, changes in primary outcomes and target sample sizes between protocols and final reports, and how issues of multiplicity are addressed in pragmatic trials.

The article was published in the Journal of Clinical Epidemiology on December 8, 2021. The authors identified 262 final reports through a search of MEDLINE and ClinicalTrials.gov. They found that co-primary outcomes are common in pragmatic trails. They also identified a need for improved transparency around design and analysis decisions involving co-primary outcomes.

Read the full article at this link.