The Journal of the American Geriatrics Society (JAGS) has published a special issue (Volume 68, S2) focused solely on the National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory and the activities and progress it has made since the September 2019 announcement.

The special issue, published online June 26, includes an introductory article describing the mission and vision of the IMPACT Collaboratory and articles from each of the 10 IMPACT cores and teams describing how they are working to achieve that mission. The introductory article authors are the two IMPACT principal investigators, Susan Mitchell, MD, MPH, senior scientist at Hebrew SeniorLife’s Hinda and Arthur Marcus Institute for Aging Research and professor of medicine at Harvard Medical School  and Vincent Mor, PhD, Professor of Health Services, Policy & Practice and the Florence Pirce Grant University Professor, Brown University School of Public Health, as well as the two executive directors, Ellen McCarthy, PhD, MPH, Associate Scientist, Marcus Institute, and Associate Professor of Medicine and Epidemiology, Harvard Medical School, and Jill Harrison, PhD, Assistant Professor of Health Services, Policy and Practice, Brown University School of Public Health.

Mitchell is guest editor for the special issue of JAGS, which includes articles from the IMPACT cores and teams to provide insight into how each is working to improve the quality and effectiveness of ePCTs in PLWD and their care partners. The article titles are:

• Achieving Health Equity in Embedded Pragmatic Trials for People Living with Dementia and Their Family Caregivers
• Building a National Program for Pilot Studies of Embedded Pragmatic Clinical Trials in Dementia Care
• Training the Workforce to Conduct Embedded Pragmatic Clinical Trials to Improve Care for People Living with Dementia and Their Caregivers
• Dissemination and Implementation of Evidence-Based Dementia Care Using Embedded Pragmatic Trials
• Ethical and Regulatory Issues for Embedded Pragmatic Trials Involving People Living with Dementia
• Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems
• Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art
• Selecting Outcomes to Ensure Pragmatic Trials Are Relevant to People Living with Dementia
• Engaging Stakeholders in the Design and Conduct of Embedded Pragmatic Clinical Trials for Alzheimer’s Disease and Alzheimer’s Disease–Related Dementias
• Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia