The IMPACT Collaboratory funds up to two Demonstration Projects annually. Projects must be conducted in partnership with a committed health care system partner, and the intervention implementation should be feasibly integrated into its clinical workflow. The intervention should address an aspect of care that is relevant to PLWD or their care partners, and the health care system delivering that care.

The feasibility of the key ePCT design features (e.g., participant enrollment, intervention implementation, outcome collection) should be supported by preliminary/pilot data. The intervention’s efficacy should be supported by evidence from prior traditional randomized clinical trials (RCTs) (NIH Stage Model II/III), with this requirement being somewhat more relaxed for simple or “nudge” (versus complex) interventions. Demonstration Projects must be powered to detect a significant difference in the primary clinical outcome between trial arms.

Awards are for two years, for up to $800,000 (total direct costs), and are non-renewable. Indirect costs are budgeted at your institution's negotiated facilities and administrative rate. Multiple Principal Investigators (MPI) are allowed, and only one application per PI/MPI is permitted in a single funding cycle.

The proposed Demonstration Project must be conducted in partnership with a committed health care system (HCS). Ideally, applicants would have an established productive collaboration with the HCS organization and key individuals within it who will help ensure the success of the ePCT. Effective and sustainable partnerships with health care delivery organizations and champions within systems are critical to implementation and testing interventions. It is expected that the intervention will be integrated into the clinical workflow or delivery of care. Demonstration Projects should be conducted within health care systems that have electronic health platforms as necessary to support the ePCT design. Outcomes or other metrics essential to taking a successful intervention to scale should be captured efficiently with minimal need for additional follow up, resources or impact on usual care. The HCS partner must facilitate the investigator’s access to all data sources necessary for the project, such as electronic health records, inpatient, outpatient, imaging, laboratory, pharmacy, and assessment data.

Investigators invited to submit full applications have multiple opportunities to access IMPACT support throughout the application preparation period. Applicants will be assigned a consultation team of experts from IMPACT Cores to help prepare strong applications. Additional one-on-one consultations are also available throughout the application period. Learn more about this support in the RFA.