Design Considerations for Embedded Pragmatic Clinical Trials of Advance Care Planning Interventions for Persons Living With Dementia

November 21, 2022

Sandra Shi, MD (2022-2023 IMPACT Faculty Scholars Program), Emily Largent, PhD, JD, RN, Ellen McCreedy, PhD, MPH, Susan Mitchell, MD, MPH describe a framework for the construction of embedded pragmatic clinical trials (ePCTs) of advance care planning (ACP) for persons living with dementia (PLWD), with a focus on distinguishing between the target of study: the PLWD, their care partners, or both. They outline specific considerations at each step of the research study process including:

1. Participant identification/eligibility
2. Participant recruitment/enrollment
3. Intervention implementation
4. Outcome selection/ascertainment

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