Measuring Mild Cognitive Impairment Using Routinely Collected Healthcare Data: A Conceptual Framework and Guidance for Embedded Pragmatic Clinical Trials November 1, 2026  A recent article published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association  by members of the IMPACT community including: Dae Hyun Kim, MD, ScD, Kevin W. McConeghy, PharmD, PhD, Jennifer L. Lund, PhD, ...

The NIA IMPACT Collaboratory is pleased to announce the 2026 Awardees for the Pilot Grants Program and the Demonstration Projects Program.  Awardees of these funding opportunities will be supported by the IMPACT cores and teams to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems (HCS) to improve care for people ...

The NIA IMPACT Collaboratory has a strong presence at the upcoming Gerontological Society of America (GSA) 2026 Annual Scientific Meeting. This year’s theme is “Reinforcing Resilience in Aging Science, Research and Education.” During the conference, IMPACT members and investigators will share work and insights across multiple sessions, symposia, and presentations: Thursday, November 5, at 10:00 PM: Is ...

A recent editorial co-authored by NIA IMPACT Collaboratory Design and Statistics Core member Thomas G. Travison, PhD, published in JAMA, examines the delicate balance between real-world flexibility and scientific rigor in pragmatic clinical trials. The article explores how researchers can generate meaningful, actionable evidence in everyday healthcare settings without sacrificing the methodological standards necessary to guide ...

Artificial Intelligence-Driven Clinical Decision Support for Postoperative Delirium Prevention: A Pragmatic Randomized Controlled Trial October 9, 2026 A recent article published in Anesthesia & Analgesia describes findings from an IMPACT Demonstration Project conducted by Ira Hofer, MD and Susana Vacas, MD, PhD that tested whether artificial intelligence–driven clinical decision support could help prevent postoperative delirium in surgical ...

In collaboration with the NEXT STEPs Network (U24AG087939) and the Long-Term Care (LTC) Data Cooperative, the National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is now accepting applications for the 2026 Real World Data Scholars Program. The 1-year mentored training program is designed to build ...

The IMPACT Collaboratory is pleased to announce plans to publish two Requests for Applications (RFA) for the 2027 Embedded Pragmatic Clinical Trials (ePCT) Planning Grants Program in early December 2026. These RFAs will focus on planning grants to improve care for people living with dementia in assisted living communities and emergency departments. The Planning Grants Program ...

Designing Pilot Studies for Embedded Pragmatic Clinical Trials September 22, 2026 A new article by IMPACT Collaboratory members Susan L. Mitchell, MD, MPH; Vincent Mor, PhD; Heather G. Allore, PhD; Thomas G. Travison, PhD; Ellen P. McCarthy, PhD, MPH; Kathleen T. Unroe, MD, MHA; Joseph E. Gaugler, PhD; Jill Harrison, PhD; and Abraham A. Brody, PhD, RN, ...

The IMPACT Collaboratory will hold the 2027 virtual ePCT Training Workshop on January 27-28, 2027, entitled . This  free 1.5-day workshop features all new material to build a foundation in practical aspects of designing and conducting ePCTs in Alzheimer’s disease (AD) and AD-related dementias (ADRD). The workshop includes a combination of engaging activities, panel discussions, small ...

Congratulations to Andrew Kiselica, PhD, Jung Kwak, PhD, MSW, and Karen Moss, PhD, RN, CNL, FNAP, FGSA, on their recent R01 Awards! Dr. Kiselica received the 2022 IMPACT Career Development Award for his project Technology Assistance in Dementia Tech-AiD to improve the care of people living with dementia and their care partners. His recent 5-year R01 for ...