The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) was established in 2019 to build the nation’s capacity to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems to improve the care of people living with dementia (PLWD) and their ...

The IMPACT Collaboratory is pleased to announce plans to publish a Request for Applications (RFA) for the Embedded Pragmatic Clinical Trials (ePCT) Planning Grants Program. The goal of this program is to support investigators, in partnership with nursing home organizations and resident-care partner advisory boards, to co-design fully specified protocols for ePCTs aimed at improving ...

The National Institute on Aging (NIA) Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory is pleased to announce the recipients of the 2025 Real World Data Scholars Program. Recipients were selected from an impressive group of competitive applications. About the Real World Data Scholars Program The Real World Data Scholars Program is a 1-year mentored training experience designed ...

The National Institute on Aging (NIA) Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory is pleased to announce the recipients of the 2025 James L. Rudolph Career Development Award Program. Recipients were selected from an impressive group of competitive applications. About the James L. Rudolph Career Development Award Program The James L. Rudolph Career Development Award recognizes promising ...

IMPACT Design and Statistics Core member Keith Goldfeld, DrPH, MS, MPA, continues his four-part blog series exploring Targeted Minimum Loss Estimation (TMLE)—a causal inference approach developed for observational studies that is increasingly relevant for randomized trials as well, including cluster randomized and stepped-wedge designs. In the latest post, Dr. Goldfeld recaps key ideas from earlier installments, ...

Using the readiness assessment for pragmatic trials (RAPT) model to structure partner engagement and strengthen pragmatic research readiness March 25, 2026 Abstract Partner engagement is critical for embedded pragmatic research, yet few structured methods guide early collaboration to strengthen feasibility and mutual understanding. In this case study, Brown University researchers and leaders from a US-based medical practice, Bluestone ...

Fan Li, PhD, assistant professor of biostatistics at Yale School of Public Health and member of IMPACT’s Design and Statistics Core, has been selected as a recipient of the 2026 Association of Schools & Programs of Public Health Early Career Research Excellence Award in recognition of his outstanding contributions as an early-career investigator. Dr. Li is ...

IMPACT Design and Statistics Core member Keith Goldfeld, DrPH, MS, MPA, has created a blog series exploring an analytic method called Targeted Minimum Loss Estimation (TMLE). TMLE is among causal inference approaches—methods first developed for observational data, but increasingly relevant for randomized trials as well. In particular, Dr. Goldfeld is digging into what TMLE can ...

March 5, 2026 – The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is pleased to announce the 2026 IMPACT Faculty Scholars. The IMPACT Collaboratory’s Faculty Scholars Program is a one-year enrichment opportunity for investigators to develop expertise in designing and conducting embedded pragmatic clinical trials ...

Uncovering treatment effect heterogeneity in pragmatic gerontology trials March 1, 2026 A recent publication by Heather Allore, PhD, and Fan Li, PhD, both members of the IMPACT Design and Statistics Core, and Guangyu Tong, PhD, a faculty scholar, demonstrates how embedding machine learning methods such as Bayesian Additive Regression Trees (BART), can help find treatment effect heterogeneity ...