Deprescribing Central Nervous System-Active Medications Among Community-Dwelling Older Adults with Dementia in Primary Care: A Feasibility Study October 22, 2025 Medications such as antipsychotics, antidepressants, and opioids that target the central nervous system (CNS) pose significant health risks for older adults with dementia, yet they remain widely prescribed. Few interventions have focused on helping this population safely ...

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory s pleased to announce a Request for Applications (RFA) for the 2025 Demonstration Projects Program. The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. These ...

Reply to: The Unseen Burden: Undiagnosed Hypoglycemia and the Need for CGM in Long-Term Geriatric Care October  17, 2025 The authors of an IMPACT Collaboratory pilot study recently published a response to a letter to the editor in the Journal of the American Geriatrics Society (JAGS) that discussed the authors’ JAGS article, Agreement Between Fingerstick Blood Glucose ...

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is pleased to announce a Request for Applications (RFA) for the 2025 Pilot Grants Program. The IMPACT Collaboratory will fund up to three awards for pilot embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems ...

The IMPACT Collaboratory is pleased to announce plans to publish Requests for Applications (RFA) for Pilot ePCT Grants and Demonstration Projects of non-pharmacologic interventions for people living with dementia (PLWD) and their care partners in mid-October 2025. Letters of Intent for both opportunities are due in November. Pilot Grants Program IMPACT will fund up to three 18-month awards ...

Ambulatory Care Follow-Up and Fragmentation After Emergency Department Visits Among Older Adults September 25 2025 IMPACT researchers Cameron J. Gettel, Julie Bynum, Yuxiao S., Craig Rothenberg, Theodore Lee, Courtney Kitchen, Yixuan Liang, Susan Hastings, and Arjun Venkatesh analyzed 55,391 ED visits from the 2015–2021 Medicare Current Beneficiary Survey to examine follow-up within 7 and 30 days and the ...

Designing Stepped Wedge Cluster Randomized Trials With a Baseline Measurement of the Outcome September 23, 2025 Stepped wedge cluster randomized trials (SW-CRTs) are a type of uni-directional crossover design that are increasingly common in prevention and implementation research. Although sample size formulas have been developed to support the planning of SW-CRTs, most methods don’t account for baseline ...

The Paul B. Beeson Emerging Leaders Career Development Award in Aging supports early-stage clinician-investigators who have begun to establish research programs and demonstrate leadership in the field of aging research.  This year’s awardees include two members from the IMPACT community! Previous IMPACT Faculty Scholar and Career Development Awardee Cameron Gettel, MD, MHS, Assistant Professor, Yale University ...

Agreement Between Fingerstick Blood Glucose and Continuous Glucose Monitor Measures Among Long-Term Care Facility Residents  August 2, 2025   A new IMPACT pilot study reveals that electronic health records (EHRs) relying on fingerstick blood glucose (FBG) data may significantly underreport hypoglycemia among long-term care (LTC) residents.  Researchers assessed how well FBG measurements recorded in EHRs aligned with continuous glucose ...

Comparative Effectiveness of Two Methods for Assigning Care Coordinators to People Living With Dementia   June 14, 2025  Investigators conducted a pragmatic clinical trial embedded in a Medicare accountable care organization exploring comparative effectiveness of two strategies for assigning care coordinators to people living with dementia (PLWD) and their caregivers.   The intervention being tested did not prove to be ...