The IMPACT Collaboratory is pleased to announce plans to publish Requests for Applications (RFA) for Pilot ePCT Grants and Demonstration Projects of non-pharmacologic interventions for people living with dementia (PLWD) and their care partners in mid-October 2025. Letters of Intent for both opportunities are due in November.

Pilot Grants Program
IMPACT will fund up to three 18-month awards for up to $300,000 pilot embedded pragmatic trials (ePCTs) that are designed to demonstrate the feasibility and inform the design of a future full-scale ePCT to evaluate non-pharmacological interventions embedded in health care system(s) for people living with dementia (PLWD) and their care partners. Learn more about previous awardees here.

RFA Release Date: October 14, 2025

LOI Due Date: November 6, 2025

Demonstration Projects Program

IMPACT will fund up to two 24-month awards of up to $800,000 for Demonstration Projects designed as full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that evaluate the effectiveness of a non-pharmacological intervention in a large-scale ePCT for people living with dementia (PLWD) and their care partners. Learn more about previous awardees here.

Learn more about previous awardees here.

RFA Release Date: October 20, 2025

LOI Due Date: November 13. 2025

Stay tuned for updates regarding the release of these RFAs. Visit IMPACTcollaboratory.org to learn more about our Grants and Training Programs.

Questions? Email us at IMPACTcollaboratory@hsl.harvard.edu.