The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is pleased to announce a Request for Applications (RFA) for the 2025 Pilot Grants Program.

The IMPACT Collaboratory will fund up to three awards for pilot embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems designed to improve care for people living with dementia (PLWD) and their care partners.

Awards are for 18 months, with funding of up to $300,000 in total direct costs. These non-renewable awards are intended to demonstrate feasibility and inform the design of a future full-scale ePCT (Stage IV effectiveness based on the NIH Stage Model).

For additional details and eligibility requirements, please read the full RFA and visit our Pilot Grants Program webpage.

Informational Webinar

An informational webinar will be held to provide an overview of the 2025 Pilot Grants Program and address applicant questions. Registration is required.
 October 23, 2025 @ 1pm ET

Letters of Intent (LOI) Application – Required

Interested applicants are required to submit an LOI. LOIs are due:
November 6, 2025 @ 11:59pm ET

 Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal due:
February 12, 2026 @ 11:59pm ET