The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory s pleased to announce a Request for Applications (RFA) for the 2025 Demonstration Projects Program.
The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. These awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners. The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.
For more information, join the informational webinar on October 30th (see details below) and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees.
Informational Webinar
Provides an overview of the program and addresses applicant questions.
Registration is required.
Thursday, October 30, 2025 @ 12:00 PM ET
Letters of Intent (LOI) Application – Required
Due: Thursday, November 13, 2025 @ 11:59pm ET
Full Proposals (By invitation only)
Applications selected for further consideration will be invited to submit a full proposal
Due: January 15, 2026 @ 11:59pm ET
If you have any questions regarding these funding opportunities, please refer to our Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu.
Please help to publicize the IMPACT funding and training opportunities and encourage your investigators and colleagues to apply.