The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is now accepting applications for the Demonstration Projects Program for non-pharmacological interventions for people living with dementia (PLWD) and their care partners.

The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. These awards support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for PLWD and their care partners. The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.

Read the full RFA here.

For more information, join the informational webinar on September 16th (see details below) and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees.

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) was established in 2019 to build the nation’s capacity to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems to improve the care of people living with dementia (PLWD) and their care partners.

This program is supported entirely through federal funding from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), under Award Number U54AG063546, totaling $17.05 million. The program is financed 100% with federal funds.

Informational Webinar

Provides an overview of the program and addresses applicant questions.
Registration is required.
September 16, 2026 @ 1:00 PM ET

Letters of Intent (LOI) Application – Required

Due: October 15, 2026 @ 11:59pm ET

Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal
Due: January 14, 2027 @ 11:59pm ET

If you have any questions regarding these funding opportunities, please refer to our Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu.

Please help to publicize the IMPACT funding and training opportunities and encourage your investigators and colleagues to apply.