Unroe co-created a video for advance care planning for nursing home residents during COVID-19

Kathleen Unroe, MD, MHA, Associate Core Leader of the IMPACT Pilot Studies Core co-created with Susan Hickman, PhD, a video for advance care planning for nursing home residents during the COVID-19 pandemic. This is an excellent resource from the Indiana University Center for Aging Research, Regenstrief Institute for people living with dementia (PLWD) and their caregivers in this setting during the COVID-19 crisis, and a reminder about the importance of advance care planning.

Find link to video here: https://youtu.be/F_cS89aa0DE

New blog post on clustered randomized trials and the design effect

The latest blog post from Keith Goldfeld, DrPH, MS, MPA, member of the executive committee of the IMPACT Collaboratory Design and Statistics Core, discusses how the design effect could provide additional insight into cluster randomized trials in his most recent blog post. The ideas in this blog post were motivated in part by Goldfeld’s work with the IMPACT Collaboratory.

Gitlin’s Tailored Activity Program highlighted in Wall Street Journal

The Tailored Activity Plan (TAP),  a home-based occupational therapy intervention shown to reduce behavioral symptoms in people living with dementia and caregiver burden, was recently included in an article in the Wall Street Journal. The TAP program was developed by Laura Gitlin, PhD, FGSA, FAAN, Dean and distinguished professor at College of Nursing and Health Professions, at Drexel University and leader of the IMPACT Collaboratory Dissemination and Implementation Core and her colleagues. Read the full article at the Wall Street Journal at this link.

Helping patients understand the results of an amyloid PET scan

SOKRATES (the Study of Knowledge and Reactions to Amyloid Testing), led by Emily Largent, PhD, and Jason Karlawish, MD from the IMPACT Collaboratory Regulation and Ethics Core, followed 80 cognitively unimpaired older adults for a year to understand the impact of learning the results of an amyloid PET scan, a common test used to determine the presence of brain amyloid, a biomarker for Alzheimer’s disease.  The results of the study were recently published in PLOS One.

Click here to read the full article at PLOS One.

Click here to read a news blog from the Penn Memory Center about the study.

Goldfeld discusses analyzing data from a stepped-wedge designed cluster randomized trial in a real-world context

Keith Goldfeld, DrPH, MS, MPA, member of the executive committee of the IMPACT Collaboratory Design and Statistics Core, recently discussed his work with the IMPACT Collaboratory on his blog, ouR data generation.

Goldfeld wrote about how to analyze data from a stepped-wedge designed cluster randomized trial. He said that this design can be an important tool to evaluate interventions in a real-world context, including research for the IMPACT Collaboratory in dementia and Alzheimers disease.

Read the full blog entry here: https://www.rdatagen.net/post/analyzing-the-open-cohort-stepped-wedge-trial-with-binary-outcomes/

Mitchell shares a look back at research in advanced dementia and links to her career

NIA IMPACT Collaboratory multiple principal investigator Susan Mitchell, MD, MPH, spoke at the February 4 Palliative and Advanced Illness Research (PAIR) Center Series at the Perelman School of Medicine at Pennsylvania University. Her talk, “Advanced Dementia: The Evolution of Research Informing Practice,” included a look at the overall body of work in advanced dementia and the evolution of her own research.

Mitchell described her research to date in three phases: Retrospective, Prospective, and Interventional, and described studies in each phase and how they contributed to the overall body of knowledge about advanced dementia. Mitchell concluded her talk with an introduction to the NIA IMPACT Collaboratory, describing how effectiveness and efficacy research continue the evolution of research in advanced dementia care.

To view the entire talk, please go to the PAIR Series site here: https://mediasite.med.upenn.edu/mediasite/Play/61d9013c63a24554bad8fa2506d1dfdd1d and begin the video at the 13:12 mark.

Rescuing Research Participants After Alzheimer Trials Stop Early

Jason Karlawish, MD and Emily Largent, PhD from the IMPACT Collaboratory Regulation and Ethics Core wrote an editorial reflecting on the unique ethical complexities around telling participants in an Alzheimer’s drug study that the study had abruptly ended. The story was also covered in the New York Times.

Click here to read the full JAMA Neurology editorial

Click here to read the article in the New York Times

Harrison outlines the need for embedded pragmatic clinical trails and how IMPACT can help in AcademyHealth editorial

Jill Harrison, PhD, Executive Director for the IMPACT Collaboratory at Brown University, authored a blog post for AcademyHealth describing the need for embedded pragmatic clinical trails and how the IMPACT Collaboratory can help.

Harrison describes the rise in diagnoses of Alzheimer’s disease and related dementias as a global public health crisis and describes how embedded pragmatic clinical trials can help to gather real world data for clinical trials, and incorporate diverse stakeholders into study design. Read the full blog post on the AcademyHealth website.

IMPACT principal investigators share their vision of the project with LeadingAge

The NIA IMPACT Collaboratory’s multiple principal investigators, Susan L. Mitchell, PhD, MPH, and Vincent Mor, PhD, shared the vision and goals of the project with LeadingAge in an article from January 17.

“We are confident that the NIA IMPACT Collaboratory will transform the delivery, quality, and outcomes of care provided to Americans with dementia, and their caregivers, by accelerating the testing and adoption of evidence-based interventions within health care systems,” says Mitchell.

The article includes a description of the problem of Alzheimer’s disease and related dementias, as well as how the structure of the IMPACT Collaboratory will help researchers who seek to conducted embedded pragmatic clinical trials to combat these conditions.

IMPACT leaders hope their collaborative efforts will identify and validate evidence-based programs that can be adopted across PLWD communities and help people live a higher quality of life. “The goal,” concludes Mor, “is to reduce the suffering of persons living with dementia, reduce the burden on the caregivers, and ease the challenge of humanely meeting the needs of this difficult-to-serve population, while maintaining their dignity—and I am confident we can achieve this.”

Read the full article at LeadingAge here.

Registration open for statistical conference focused on cluster randomized clinical trials

IMPACT Steering Committee and Design and Statistics Core member Monica Taljaard, PhD, will be part of a panel at the 13th University of Pennsylvania Conference on Statistical Issues in Clinical Trials  on April 29th.  The conference will focus on challenges and opportunities in cluster randomized clinical trials. Registration is now open.