Uncovering treatment effect heterogeneity in pragmatic gerontology trials
March 1, 2026
Research Grants
IMPACT Collaboratory announces release of funding for 2025 Pilot Grants Program
The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is pleased to announce a Request for Applications (RFA) for the 2025 Pilot Grants Program.
The IMPACT Collaboratory will fund up to three awards for pilot embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems designed to improve care for people living with dementia (PLWD) and their care partners.
Awards are for 18 months, with funding of up to $300,000 in total direct costs. These non-renewable awards are intended to demonstrate feasibility and inform the design of a future full-scale ePCT (Stage IV effectiveness based on the NIH Stage Model).
For additional details and eligibility requirements, please read the full RFA and visit our Pilot Grants Program webpage.
Informational Webinar
An informational webinar will be held to provide an overview of the 2025 Pilot Grants Program and address applicant questions. Registration is required.
October 23, 2025 @ 1pm ET
Letters of Intent (LOI) Application – Required
Interested applicants are required to submit an LOI. LOIs are due:
November 6, 2025 @ 11:59pm ET
Full Proposals (By invitation only)
Applications selected for further consideration will be invited to submit a full proposal due:
February 12, 2026 @ 11:59pm ET
Gitlin and Kales share tips for care partners of people living with dementia in NYT article
IMPACT Implementation Core Leader, Laura Gitlin, PHD, FGSA, FAAN, and IMPACT Pilot Grant Awardee, Helen Kales, MD are quoted in the recent New York Times article, “How to care for a loved one with dementia: 5 Expert Tips,” by Isabelle Taft.
The article highlights the challenges to family members providing care for people living with dementia and tips of support. Dr. Gitlin describes the importance of full disclosure about the course of the disease to help individuals and family caregivers prepare and stresses the need to check in on caregivers. Dr. Kales encourages people living with dementia and their care partners to avoid the temptation for isolation and remain social. Other recommendations in the article include establishing a caregiving team, seeking help from experts, and considering using technology that can help monitor loved ones.