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LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine

Posted on by Josee Meehan

December 2025 - In Grand Rounds 61, Amber Watts, PhD and Amanda N. Szabo-Reed, PhD discuss “LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.”

Speakers

Amber Watts, PhD
Associated Professor
University of Kansas
Director, BRANCH LAb

Amanda N. Szabo-Reed, PhD
Research Associate Professor
University of Kansas Medical Center

Webinar Slides

Learning Objectives

  • Understand why exercise is important for Alzheimer’s disease prevention.
  • Recognize barriers to translating exercise research into clinical practice.
  • Learn how the LEAP! Rx trial was designed and implemented.
  • Compare outcomes and adherence between physician-referred and self-referred participants.
  • Explore strategies for supporting long-term exercise habits in older adults.

Using pragmatic trials to address prescription safety in older patients with diabetes

Posted on by Josee Meehan

November 2025 - In Grand Rounds 60, Richard W. Grant, MD, MPH discusses "Using pragmatic trials to address prescription safety in older patients with diabetes."

Speakers

Richard W. Grant, MD, MPH 
Research Scientist
Kaiser Permanente Division of Research, Kaiser Permanente Northern California

Webinar slides

Learning Objectives

  • Understand how pragmatic clinical trials improve prescription safety for older adults with diabetes
  • Explore deprescribing strategies and barriers in diabetes care
  • Review key findings from the RETRO-DM and SAGE studies
  • Learn practical interventions for safer diabetes management, including academic detailing and technology-enabled hypoglycemia prevention

Building the NEXT STEPs Network

Posted on by Josee Meehan

October 2025 – In Grand Rounds 59, Kathleeen Unroe, MD, MHA, MS discusses “Building the NEXT STEPs Network.”

Speaker

Kathleen Unroe, MD, MHA, MS (she/hers)
CEO
Probari, Inc.

Webinar Slides

Learning Objectives

  • Understand the need for rigorous clinical trials and research infrastructure to improve nursing home care
  • Recognize the importance of building collaborative networks and partnerships to address knowledge gaps in nursing home research
  • Reflect on strategies and resources for supporting equitable, high-quality clinical trials in nursing homes, including recruitment, retention, and engagement of diverse stakeholders

Current and future use of RE-AIM and its PRISM expansion, and their application in pragmatic trials

Posted on by Mia

June 2024 – In Grand Rounds 48, Dr. Glasgow details RE-AIM and PRISM, an integrated framework designed to improve the adoption and sustainable implementation of evidence-based interventions in a wide range of public health, educational, community, and other settings.

Speaker

Photo of Dr. Russell GlasgowRussell Glasgow, PhD

Research Professor, Dept. of Family Medicine

Director, ACCORDS Dissemination & Implementation Science (D&I) Program

University of Colorado Anschutz Medical Campus

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Learning Objectives

  • Describe key features of the RE-AIM framework and how it can be applied for pragmatic research.
  • Discuss how the PRISM framework expands upon RE-AIM and how it is used to address health equity.
  • Discuss the importance of adaptations and the issues involved with iterative adaptations during implementation.

 

Podcast

 

Podcast Transcript: Download the transcript here.

The GUIDE Model: A CMS payment model test to support people living with dementia and their family caregivers

Posted on by Mia

May 2024 – In Grand Rounds 47, Drs. Epstein-Lubow and Lees-Haggerty, along with Tonya Saffer, Director of the Division of Healthcare Payment Models with the Centers for Medicare & Medicaid Services (CMS), share the GUIDE Model. GUIDE is a CMS payment model that tests whether dementia care programs can improve quality of life for people living with dementia and their caregivers.

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Headshot photo of Dr. Gary Epstein-Lubow

 

 

 

 

 

Gary Epstein-Lubow, MD
Team Lead, Engaging Partners Team
Distinguished Medical Scholar, EDC
Associate Professor, Brown University

Headshot photo of Dr. Kristin Lees-Haggerty

 

 

 

 

 

Kristin Lees-Haggerty, PhD
Project Director
Natl. Collaboratory to Address Elder Mistreatment
Education Development Center

Headshot photo of Tonya Saffer

 

 

 

 

 

Tonya Saffer, MPH
Director
Division of Healthcare Payment Models
Centers for Medicare & Medicaid Services

Learning Objectives

  • Review the historical context of the CMS GUIDE Model and its potential for transforming the delivery, quality and outcomes of dementia care in the United States.
  • Learn the requirements for participating health systems regarding care delivery and outcomes reporting.
  • Understand how the GUIDE Model requirements align with evidence-based comprehensive dementia care, including new opportunities and challenges for pragmatic evaluation of dementia service delivery related to GUIDE-participating health systems.

Podcast

 

Podcast Transcript: Download the transcript here.
IMPACT April 2024 Grand Rounds with Professor Clive Ballard from the University of Exeter

The WHELD Programme

Posted on by Mia

April 2024 – In Grand Rounds 46, Dr. Ballard speaks on the WHELD programme  – an evidence-based program developed to coach and support care home staff to deliver better person-centered care and increase opportunities for social interactions with personalized activities for residents living with dementia.

 

Speaker

Clive Ballard, MD, MPHClive Ballard, MD, MPH

Professor of Age-Related Diseases

University of Exeter

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Learning Objectives

  • Understanding some of the challenges for nursing homes and people with dementia living in these settings
  • Understanding the impacts of psychotropic medications in nursing home residents with dementia
  • Understanding the best evidence regarding interventions to improve outcomes for nursing home residents with dementia

 

Podcast

 

Podcast Transcript: Download the transcript here.

Meeting the Challenge of Caring for Persons Living with Dementia and Their Care Partners and Caregivers – A Way Forward

Posted on by Erin Luers

The Mission Moment for the 2024 IMPACT Annual Business Meeting was provided by the distinguished Eric Larson, MD, MPH, a professor at University of Washington, retired executive director of Kaiser Permanente Washington Health Research Institute and vice president for research and healthcare innovation at Kaiser Foundation Health Plan of Washington, and former Leader of IMPACT’s Health Care Systems Core. Dr. Larson began by reminding the group about how far the field has come in the last 60 years and called on researchers and healthcare providers to follow the Guiding Principles for Dementia Care, as described in "Meeting the Challenge of Caring for Persons Living with Dementia and Their Care Partners and Caregivers – A Way Forward" released in February 2021 from the National Academies of Sciences, Engineering and Medicine. These principles include:

  • person-centeredness
  • promotion of well-being
  • attention to each person’s needs with respect and dignity
  • justice
  • racial, ethnic, sexual, cultural, and linguistic, inclusivity
  • accessibility and affordability

Graphic with headshot of Dr. Julie Bynum from the shoulders up, next to the words "Grand Rounds & Podcast March 2024"

Diagnosed Dementia in Medicare: Benchmarking for Study Planning and Equity

Posted on by Mia

March 2024 – In Grand Rounds 45, Dr. Bynum shares the pros and cons of using healthcare-generated data, such as Medicare Fee-for-Service and Medicare Advantage, to identify people living with Alzheimer's disease and related dementias (ADRD), as well as the use of population benchmarks in study planning and integrating health equity.

 

Speaker

Dr. Julie BynumJulie Bynum, MD, MPH

Margaret Terpenning Collegiate Professor of Internal Medicine

Division of Geriatric & Palliative Medicine

University of Michigan


 
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Learning Objectives

  • Identify strengths & challenges when using Medicare data for participant identification
  • Understand characteristics of diagnosed dementia cases across place
  • Consider value of using population benchmarks for planning and equity

 

Podcast

 

Podcast Transcript: Download the transcript here.
February 2024 Grand Rounds: Cultural adaptations of ADRD clinical trials for Latino Participants

Cultural adaptation of ADRD clinical trials for Latino participants

Posted on by Mia

February 2024 – In Grand Rounds 44, Drs. Hanson, Lum, Ramirez Gomez, and Fischer discuss barriers to inclusivity in ADRD clinical trials, disparities in caregiving of PLWD, the importance of integrating cultural adaptations and lessons learned from the ADRD-PC trial.

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Stacy Fischer, MD

Stacy Fischer, MD

Professor

University of Colorado Anschutz Medical Campus

 

Hillary Lum, MD, PhD

Hillary Lum, MD, PhD

Associate Professor

University of Colorado Anschutz Medical Campus

 

Laura Hanson, MD, MPHLaura Hanson, MD, MPH

Professor

University of North Carolina School of Medicine

 

Liliana Ramirez Gomez. MDLiliana Ramirez Gomez, MD

Clinical Director

Massachusetts General Hospital

Learning Objectives

  • Review the barriers to ADRD research for diverse populations
  • Learn best practices for engaging Latino ADRD caregiver advisors in research
  • Understand the process of cultural adaptation of ADRD research protocols

 

Podcast

 

Podcast Transcript: Download the transcript here.
Graphic with headshots of Drs. McCreedy, Sadarangani, and Zimmerman from the shoulders up, next to the words "Grand Rounds & Podcast. January 2024"

Strategies to Implement ePCTs in Home and Community-Based Settings – Issues and Successes in Assisted Living and Adult Day Centers

Posted on by dcridigital

January 2024 – In Grand Rounds 43, Drs. McCreedy, Sadarangani, and Zimmerman note common challenges that arise when conducting ePCTs in home and community-based, long-term care settings and suitable solutions to address these challenges.

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Ellen McCreedy, PhD

Assistant Professor

Brown University School of Public Health

 

Tina Sadarangani,
PhD, RN

Associate Professor

NYU Rory Meyers College of Nursing

Sheryl Zimmerman, PhD

University Distinguished Professor

University of North Carolina at Chapel Hill

Learning Objectives

  • Understand the national scope of assisted living and adult day centers (i.e., home and community-based settings)
  • Recognize common challenges conducting ePCTs in home and community-based settings
  • Be familiar with strategies to address challenges conducting ePCTs in home and community-based settings

Podcast

 

Podcast Transcript: Download the transcript here.