February 2026 - Grand Rounds 63, Dr. Donna Spiegelman discusses Learning as You Go (LAGO) Design.
Speaker
Donna Spiegelman, ScD
Professor
Yale School of Public Health
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Home Time as a Patient-Centered Outcome in Pragmatic Trials: Promise, Pitfalls, and the Path Forward
Professor, Division of Geriatric Medicine and Director, UNC Palliative Care Program, University of North Carolina School of Medicine
Claire Ankuda, MD, MPH
Associate Professor, Icahn School of Medicine at Mount Sinai
Associate Director of Marcus Institute for Aging Research, Associate Professor of Medicine, Harvard Medical School
Courtney Van Houtven, PhD
Professor, Population Health Sciences, Duke University School of Medicine and Duke-Margolis Institute for Health Policy
Learning Objectives
- Understand the concept of home time as a patient‑centered, system‑relevant outcome measure and how it is operationalized across different clinical contexts.
- Recognize the limitations, measurement challenges, and equity concerns associated with using home time as an outcome or performance metric in pragmatic clinical trials.
- Reflect on emerging evidence and future directions for developing more person‑centered home time measures that better capture quality of life for older adults and caregivers.
Building the NEXT STEPs Network
October 2025 – In Grand Rounds 59, Kathleeen Unroe, MD, MHA, MS discusses “Building the NEXT STEPs Network.”
Speaker
Kathleen Unroe, MD, MHA, MS (she/hers)
CEO
Probari, Inc.
Learning Objectives
- Understand the need for rigorous clinical trials and research infrastructure to improve nursing home care
- Recognize the importance of building collaborative networks and partnerships to address knowledge gaps in nursing home research
- Reflect on strategies and resources for supporting equitable, high-quality clinical trials in nursing homes, including recruitment, retention, and engagement of diverse stakeholders
Meta Lessons Learned from Pilot and Demonstration Projects Implementation
June 2025 – In Grand Rounds 57, Jennifer Sullivan, PhD, describes lessons learned from IMPACT Pilot and Demonstration Projects implementation data.
Speakers
Jennifer Sullivan, PhD
Associate Professor, Brown University School of Public Health
Department of Health Service, Policy and Practice
Associate Director & Investigator
THRIVE COIN
VA Providence Healthcare System
Learning Objectives
- Describe factors enabling and/or hindering pilot and demonstration project implementation
- Understand which implementation strategies were being used by pilot and demonstration grants
- Gain knowledge about how implementation progress was made by programs over the funding timelines
Bridging Research and Practice: An Update from Real World Data Scholars
May 2025 – In Grand Rounds 56, the 2023 Real World Data Scholars presented on their research projects using the Long-Term Care (LTC) Data Cooperative dataset.
Boston University Chobanian & Avedisian School of Medicine
Validating Medication Orders by Leveraging Natural Language Processing
University of Pennsylvania Perelman School of Medicine
Determination of Cognitive Status in NH Residents: The Utility of EHR Data
Weill Cornell Medical College
Evaluating LTC Data Cooperative EHRs to Study T2D among Nursing Home Residents
Improving Advance Care Planning for Seriously Ill Primary Care Patients: UC Health Care Planning Study
January 2025 - In Grand Rounds 52, Rebecca Sudore, MD, and Anne Walling, MD, PhD, present on "Improving Advance Care Planning (ACP) for Seriously Ill Primary Care Patients: UC Health Care Planning Study". They discuss the evolving ACP definition and research, along with lessons learned from their ACP PCORI pragmatic randomized control trial.
Speakers
Rebecca Sudore, MD
Professor of Medicine,
University of California,
San Francisco
Anne Walling, MD, PhD
Professor-in-Residence,
University of California,
Los Angeles
Learning Objectives
- The Evolving ACP Definition & Research
- Lessons for an ACP PCORI Pragmatic RCT
- Identifying the cohort with validated algorithms
- Constructing the ACP EMR Intervention Infrastructure
- Healthcare navigator arm
- Trial outcomes: NLP
- Implementation Lessons
COVID Vaccination among Medicare Beneficiaries: Findings from an IMPACT Supplement
December 2024 - In Grand Rounds 51, Drs. Kaley Hayes, PharmD, PhD & Daniel Harris, PhD, MPH discuss the COVid VAXines Effects on the Aged (COVVAXAGE) database, which was the first project with NIA LINKAGE program (external data linkage to CMS data in NIA-funded projects); they walk through associated papers and lessons learned working with industry partners CVS Health and Walgreens.
Speakers
Daniel Harris, PhD, MPH
Assistant Professor
University of Delaware
Kaley Hayes, PharmD, PhD
Assistant Professor
Brown University
Learning Objectives
- Be familiar with the NIA Linkage program and COVVAXAGE linked database of Medicare claims.
- Understand the benefits of data linkages to Medicare data for studying COVID-19 vaccines and clinical outcomes.
- Discuss findings from real-world COVID-19 vaccine studies examining use, safety, and effectiveness among older adults in the US.
Using Pilot Studies to Inform ePCTs in Hispanic/Latino People Living with Dementia and their Care Partners
October 2024 - In Grand Rounds 50, Drs. Ramirez and Samper-Ternent describe "Using Pilot Studies to Inform ePCTs in Hispanic/Latino People Living with Dementia and their Care Partners"
Speakers
Maggie Ramirez, PhD, MS, MS
Assistant Professor
University of Washington School of Public Health
Rafael Samper-Ternent, MD, PhD
Associate Professor
UTHealth Houston
Learning Objectives
- Understand background of Hispanics/Latinos with Dementia
- Describe Cultural Adaptation of Patient Priority Care using the Ecological Validity Model (EVM) and Heuristic Framework
- Describe the key stages in culturally adapting an evidence-based intervention
- Provide specific adaptations made to STAR-C for Latino caregivers
- Apply these insights to enhance your own work with family caregivers
Evidence for Reducing Infections, Hospitalizations, and Antibiotic Resistant Pathogens in Nursing Homes through Universal Nasal Decolonization & Bathing with Chlorhexidine
September 2024 – In Grand Rounds 49, Dr. Huang presents on "Evidence for Reducing Infections, Hospitalizations, and Antibiotic Resistant Pathogens in Nursing Homes through Universal Nasal Decolonization & Bathing with Chlorhexidine."
Speakers
Susan Huang, MD, MPH
Professor, Infectious Diseases,
Medical Director, Epidemiology and Infection Prevention,
University of California Irvine School of Medicine
Learning Objectives
- Review the rise and risks of MultiDrug-Resistant Organisms (MDROs) in nursing homes (NH)
- Describe decolonization, why it’s needed, and how it works; focusing on Chlorhexidine
- Review clinical trial evidence for decolonization in hospitals and NHs
- Summarize the NH Decolonization Toolkit and implementation
Current and future use of RE-AIM and its PRISM expansion, and their application in pragmatic trials
June 2024 – In Grand Rounds 48, Dr. Glasgow details RE-AIM and PRISM, an integrated framework designed to improve the adoption and sustainable implementation of evidence-based interventions in a wide range of public health, educational, community, and other settings.
Speaker
Russell Glasgow, PhD
Research Professor, Dept. of Family Medicine
Director, ACCORDS Dissemination & Implementation Science (D&I) Program
University of Colorado Anschutz Medical Campus
Learning Objectives
- Describe key features of the RE-AIM framework and how it can be applied for pragmatic research.
- Discuss how the PRISM framework expands upon RE-AIM and how it is used to address health equity.
- Discuss the importance of adaptations and the issues involved with iterative adaptations during implementation.