Dissemination and Implementation of Evidence-Based Dementia Care Using Embedded Pragmatic Trials
June 26, 2020
Topics
NIA IMPACT Collaboratory Featured in JAGS Special Issue
The Journal of the American Geriatrics Society (JAGS) has published a special issue (Volume 68, S2) focused solely on the National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory and the activities and progress it has made since the September 2019 announcement.
The special issue, published online June 26, includes an introductory article describing the mission and vision of the IMPACT Collaboratory and articles from each of the 10 IMPACT cores and teams describing how they are working to achieve that mission. The introductory article authors are the two IMPACT principal investigators, Susan Mitchell, MD, MPH, senior scientist at Hebrew SeniorLife’s Hinda and Arthur Marcus Institute for Aging Research and professor of medicine at Harvard Medical School and Vincent Mor, PhD, Professor of Health Services, Policy & Practice and the Florence Pirce Grant University Professor, Brown University School of Public Health, as well as the two executive directors, Ellen McCarthy, PhD, MPH, Associate Scientist, Marcus Institute, and Associate Professor of Medicine and Epidemiology, Harvard Medical School, and Jill Harrison, PhD, Assistant Professor of Health Services, Policy and Practice, Brown University School of Public Health.
Mitchell is guest editor for the special issue of JAGS, which includes articles from the IMPACT cores and teams to provide insight into how each is working to improve the quality and effectiveness of ePCTs in PLWD and their care partners. The article titles are:
- Achieving Health Equity in Embedded Pragmatic Trials for People Living with Dementia and Their Family Caregivers
- Building a National Program for Pilot Studies of Embedded Pragmatic Clinical Trials in Dementia Care
- Training the Workforce to Conduct Embedded Pragmatic Clinical Trials to Improve Care for People Living with Dementia and Their Caregivers
- Dissemination and Implementation of Evidence-Based Dementia Care Using Embedded Pragmatic Trials
- Ethical and Regulatory Issues for Embedded Pragmatic Trials Involving People Living with Dementia
- Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems
- Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art
- Selecting Outcomes to Ensure Pragmatic Trials Are Relevant to People Living with Dementia
- Engaging Stakeholders in the Design and Conduct of Embedded Pragmatic Clinical Trials for Alzheimer’s Disease and Alzheimer’s Disease–Related Dementias
- Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia
Goldfeld Blog Post: Consider a permutation test for a small pilot study
Check out the latest blog post from Keith Goldfeld, DrPH, MS, MPA, executive committee member of the IMPACT Design and Statistics Core. Goldfeld considers the use of a permutation test for a small pilot study.
Link: https://www.rdatagen.net/post/permutation-test-for-a-covid-19-pilot-nursing-home-study/
Finding Pragmatic and Relevant Outcomes for AD/ADRD ePCTs
June 2020 – Grand Rounds 7, members of IMPACT's Patient Caregiver Relevant Outcomes Core describe person and caregiver-centered outcome measurement in AD/ADRD ePCTs, give an overview of how outcomes are mapped to care domains, and highlight the methodological challenges present in AD/ADRD and pragmatic research.
Speakers
Laura C. Hanson, MD, MPH
Core Leader, Patient/Caregiver Relevant Outcomes Core
Member, Steering Committee
Professor, Division of Geriatric Medicine
Director, UNC Palliative Care Program
University of North Carolina School of Medicine
Sheryl Zimmerman, PhD
Executive Committee, Patient/Caregiver Relevant Outcomes (PCRO) Core
University Distinguished Professor and Co-Director, Program on Aging, Disability, and Long-Term Care, Cecil G. Sheps Center for Health Services Research
University of North Carolina at Chapel Hill
Learning Objectives
- Describe outcomes relevant for people living with dementia and their caregivers
- Describe the application of the Alzheimer’s Association conceptual framework to link care interventions to outcomes
- Describe considerations for selecting outcome measures for AD/ADRD ePCTs
Covid-19 Among Older Persons in Health Care Systems: Pragmatic Responses to the Crisis
June 2020 – In this Special Grand Rounds, Drs. Lipsitz, Rudolph, and White discuss their ongoing projects to meet the unique challenges COVID-19 presents managing care of older persons.
Lewis Lipsitz, MD
Marcus Institute for Aging Research
Hebrew SeniorLife
James Rudolph, MD
Brown University
Elizabeth White, PhD, ARPN
Brown University
Learning Objectives
- Describe key ethical issues raised by pragmatic RCTs and which may be particularly salient to the ADRD context
- Describe the challenges of identifying a sample of pragmatic RCTs from the literature
- Describe the landscape of key ethical issues in published pragmatic RCTs in ADRD
Mission Moment: Louise Phillips, MD
The mission of the NIA IMPACT Collaboratory is to build the nation’s capacity to conduct pragmatic clinical trials of interventions embedded within health care systems for people living with dementia and their care partners. Our Mission Moments highlight the perspective of someone directly involved with dementia to remind us of the importance of our mission. In this Mission Moment, Louise Phillips, MD shares her experience as a person living with dementia and a retired physician.