March 2023 – In Grand Rounds 35, Dr. Eleanor "Ellie" Murray explores causal inference in randomized pragmatic trials highlighting topics such as immortal time bias, per-protocol effects, and how to use the SMARTER acronym when thinking about causal research questions.
Eleanor Murray, PhD
Assistant Professor
Epidemiology
Boston University School of Public Health
@EpiEllie
February 2023 – In Grand Rounds 34, IMPACT Design and Statistics Executive Committee Member, Dr. Li, sheds light on several methods for designing cluster randomized trials (CRTs) to detect the variability of treatment effects for individuals within a population, also known as heterogeneity of treatment effect (HTE).
January 2023 – In Grand Rounds 33, Dr. Wiltsey Stirman dives into the adaptations of behavioral interventions and describes how the FRAME process can be used to document those adaptations and modifications.
Shannon Wiltsey Stirman, PhD
Associate Professor
Psychiatry and Behavioral Sciences
Stanford University
December 2022 – In Grand Rounds 32, Drs. Mark Neuman and Justin Clapp share results from the REGAIN trial on enrolling and retaining people living with dementia in pragmatic trials involving spinal vs. general anesthesia for hip fracture surgery.
Mark Neuman, MD, MSc
Horatio C. Wood Associate Professor of
Anesthesiology & Critical Care
University of Pennsylvania
Perelman School of Medicine
No Grand Rounds recording, but check out the podcast!
Justin Clapp, PhD, MPH
Assistant Professor
Anesthesiology & Critical Care
Medical Ethics & Health Policy
University of Pennsylvania
Perelman School of Medicine
November 2022 – In Grand Rounds 31, Dr. Weijer shares six different vulnerabilities, and key methods of protection to address them, in cluster randomized trials for people living with dementia in long-term care home settings.
Charles Weijer, MD, PhD
Professor
Western University
October 2022 – In Grand Rounds 30, Dr. Richesson describes the use of electronic health records (EHR) to develop standards and quality metrics for computable phenotyping in pragmatic clinical trials.
Rachel Richesson, PhD, MPH, FACMI
Professor
Informatics & Learning Health Sciences
University of Michigan School of Medicine
September 2022 – In Grand Rounds 29, Dr. Kristi Williams, professor and nurse gerontologist at the University of Kansas, shares results and updates on the intervention, CHATO, for long-term care residents with Alzheimer's disease and other related dementias.
Kristi Williams, PhD, RN
Professor
University of Kansas School of Nursing
Podcast transcript: Download the transcript here.
The NIH Pragmatic Trials Collaboratory aims to improve the way clinical trials are conducted by creating a new infrastructure for collaborative research with healthcare systems, ultimately ensuring that healthcare providers and patients can make decisions based on the best available clinical evidence. The Collaboratory supports the design and rapid execution of pragmatic clinical trial Demonstration Projects to address questions of major public health importance and engage healthcare delivery systems in research partnerships. The Collaboratory also provides training resources on how to design, conduct, and disseminate embedded pragmatic clinical trials (ePCTs).
June 2022 – In Grand Rounds 28, Drs. Jennifer Gabbard and Ariel Green share research updates and experiences on IMPACT Cycle 2A Pilot Studies.
Jennifer Gabbard, MD on her pilot: Using Telemedicine to Improve Engagement in Advance Care Planning in Patients with Cognitive Impairment or Unrecognized Dementia
Ariel Green, MD, MPH, PhD on her pilot: ALIGN: Aligning Medications with What Matters Most
Jennifer Gabbard, MD
Assistant Professor
Geriatrics and Palliative Medicine
Wake Forest School of Medicine
Ariel Green, MD, MPH, PhD
Associate Professor
Geriatrics Medicine and Gerontology
Johns Hopkins University School of Medicine
May 2022 – In Grand Rounds 27, the NIA IMPACT Collaboratory collaborated with the US Deprescribing Research Network (USDeN) to present on the OPTIMIZE Pragmatic Cluster Randomized Trial.
Elizabeth Bayliss, MD, MSPH
Senior Investigator
Institute for Health Research
Kaiser Permanente Colorado
Professor of Family Medicine
University of Colorado School of Medicine
Cynthia Boyd, MD, MPH
Professor
Medicine, Epidemiology, and Health Policy & Management
Johns Hopkins University School of Medicine
