The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is now accepting applications for the 2025 Career Development Award (CDA) Program. These CDAs support the development of MD, PhD, or equivalent researchers who seek careers conducting embedded pragmatic clinical trials (ePCTs) for people living with AD/ADRD and their care partners.

This mechanism will fund research projects that are preparatory to conducting a future ePCT such as secondary data analysis, intervention development or the development of outcomes to be used in ePCTs. The proposed CDA project cannot include a clinical trial (including pilot trials; see NIH definition of a clinical trial).

The IMPACT Collaboratory will fund up to two Career Development Awards (CDAs). Each award will provide $240,000 in total direct costs over two years, and facilities and administrative (indirect) costs may not exceed 8% of total direct costs. Each year, at least $20,000 in direct costs must be allocated for research-related expenses, such as travel, publication costs, analytic, technical or project support, data acquisition, certified translations, or other activities directly related to the goals of the award. Awardees are required to devote a minimum of 50% effort toward the goals of the award.

Read the full RFA here

For more information, join the optional informational webinar on December 3^rd (see details below) and visit our Career Development Award Program webpage.  Learn more about previous awardees here.

Informational Webinar

An informational webinar will provide an overview of the program and address applicant questions. Registration is required. 

Wednesday, December 3, 2025 @ 12:00 PM ET

Applications

Due: January 15, 2026 @ 11:59 PM ET

If you have any questions regarding these funding opportunities, please refer to our Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu.

Please help to publicize the IMPACT funding and training opportunities and encourage your investigators and colleagues to apply.

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory s pleased to announce a Request for Applications (RFA) for the 2025 Demonstration Projects Program.

The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. These awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners. The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.

Read the full RFA here.

For more information, join the informational webinar on October 30th (see details below) and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees.

Informational Webinar

Provides an overview of the program and addresses applicant questions.
Registration is required.
 Thursday, October 30, 2025 @ 12:00 PM ET

Letters of Intent (LOI) Application – Required

Due: Thursday, November 13, 2025 @ 11:59pm ET

Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal
Due: January 15, 2026 @ 11:59pm ET

If you have any questions regarding these funding opportunities, please refer to our Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu.

Please help to publicize the IMPACT funding and training opportunities and encourage your investigators and colleagues to apply.