October 27, 2025 Continue reading
News
IMPACT Collaboratory announces release of funding for the 2025 Demonstration Projects Program
The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory s pleased to announce a Request for Applications (RFA) for the 2025 Demonstration Projects Program.
The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. These awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners. The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.
For more information, join the informational webinar on October 30th (see details below) and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees.
Informational Webinar
Provides an overview of the program and addresses applicant questions.
Registration is required.
Thursday, October 30, 2025 @ 12:00 PM ET
Letters of Intent (LOI) Application – Required
Due: Thursday, November 13, 2025 @ 11:59pm ET
Full Proposals (By invitation only)
Applications selected for further consideration will be invited to submit a full proposal
Due: January 15, 2026 @ 11:59pm ET
If you have any questions regarding these funding opportunities, please refer to our Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu.
Please help to publicize the IMPACT funding and training opportunities and encourage your investigators and colleagues to apply.
IMPACT Collaboratory announces release of funding for 2025 Pilot Grants Program
The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory is pleased to announce a Request for Applications (RFA) for the 2025 Pilot Grants Program.
The IMPACT Collaboratory will fund up to three awards for pilot embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems designed to improve care for people living with dementia (PLWD) and their care partners.
Awards are for 18 months, with funding of up to $300,000 in total direct costs. These non-renewable awards are intended to demonstrate feasibility and inform the design of a future full-scale ePCT (Stage IV effectiveness based on the NIH Stage Model).
For additional details and eligibility requirements, please read the full RFA and visit our Pilot Grants Program webpage.
Informational Webinar
An informational webinar will be held to provide an overview of the 2025 Pilot Grants Program and address applicant questions. Registration is required.
October 23, 2025 @ 1pm ET
Letters of Intent (LOI) Application – Required
Interested applicants are required to submit an LOI. LOIs are due:
November 6, 2025 @ 11:59pm ET
Full Proposals (By invitation only)
Applications selected for further consideration will be invited to submit a full proposal due:
February 12, 2026 @ 11:59pm ET
Notice of Intent (NOI) to Publish Two New Funding Opportunities Later in October
The IMPACT Collaboratory is pleased to announce plans to publish Requests for Applications (RFA) for Pilot ePCT Grants and Demonstration Projects of non-pharmacologic interventions for people living with dementia (PLWD) and their care partners in mid-October 2025. Letters of Intent for both opportunities are due in November.
Pilot Grants Program
IMPACT will fund up to three 18-month awards for up to $300,000 pilot embedded pragmatic trials (ePCTs) that are designed to demonstrate the feasibility and inform the design of a future full-scale ePCT to evaluate non-pharmacological interventions embedded in health care system(s) for people living with dementia (PLWD) and their care partners. Learn more about previous awardees here.
RFA Release Date: October 14, 2025
LOI Due Date: November 6, 2025
Demonstration Projects Program
IMPACT will fund up to two 24-month awards of up to $800,000 for Demonstration Projects designed as full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that evaluate the effectiveness of a non-pharmacological intervention in a large-scale ePCT for people living with dementia (PLWD) and their care partners. Learn more about previous awardees here.
Learn more about previous awardees here.
RFA Release Date: October 20, 2025
LOI Due Date: November 13. 2025
Stay tuned for updates regarding the release of these RFAs. Visit IMPACTcollaboratory.org to learn more about our Grants and Training Programs.
Questions? Email us at IMPACTcollaboratory@hsl.harvard.edu.
Congratulations to IMPACT community members for receiving the 2025 Beeson Award
The Paul B. Beeson Emerging Leaders Career Development Award in Aging supports early-stage clinician-investigators who have begun to establish research programs and demonstrate leadership in the field of aging research. This year’s awardees include two members from the IMPACT community!
Previous IMPACT Faculty Scholar and Career Development Awardee Cameron Gettel, MD, MHS, Assistant Professor, Yale University received the award for Development and pilot testing of a novel text messaging intervention to improve emergency department care transitions among care partners of persons living with cognitive impairment.
Previous IMPACT Faculty Sholar Sandra Shi, MD, MPH, Geriatric Specialist, Hebrew Rehabilitation Center for the Aged received the award for Strengthening Recovery – Integrating Intrinsic Capacity Care into Post-Acute Skilled Nursing Facilities.
