January 31, 2026 Continue reading
Resource Type
Home Time as a Patient-Centered Outcome in Pragmatic Trials: Promise, Pitfalls, and the Path Forward
Professor, Division of Geriatric Medicine and Director, UNC Palliative Care Program, University of North Carolina School of Medicine
Claire Ankuda, MD, MPH
Associate Professor, Icahn School of Medicine at Mount Sinai
Associate Director of Marcus Institute for Aging Research, Associate Professor of Medicine, Harvard Medical School
Courtney Van Houtven, PhD
Professor, Population Health Sciences, Duke University School of Medicine and Duke-Margolis Institute for Health Policy
Learning Objectives
- Understand the concept of home time as a patient‑centered, system‑relevant outcome measure and how it is operationalized across different clinical contexts.
- Recognize the limitations, measurement challenges, and equity concerns associated with using home time as an outcome or performance metric in pragmatic clinical trials.
- Reflect on emerging evidence and future directions for developing more person‑centered home time measures that better capture quality of life for older adults and caregivers.
LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine
December 2025 - In Grand Rounds 61, Amber Watts, PhD and Amanda N. Szabo-Reed, PhD discuss “LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.”
Speakers
Amber Watts, PhD
Associated Professor
University of Kansas
Director, BRANCH LAb
Amanda N. Szabo-Reed, PhD
Research Associate Professor
University of Kansas Medical Center
Learning Objectives
- Understand why exercise is important for Alzheimer’s disease prevention.
- Recognize barriers to translating exercise research into clinical practice.
- Learn how the LEAP! Rx trial was designed and implemented.
- Compare outcomes and adherence between physician-referred and self-referred participants.
- Explore strategies for supporting long-term exercise habits in older adults.
The IMPACT Collaboratory Lived Experience Panel: Reflections on Accomplishments and Recommendations for Continued Work
This extended summary report, authored by Yaideliz M. Romero-Ramos, a Brown University graduate student and Health Equity Scholar, describes feedback from Lived Experience Panel members about their involvement with the panel to date and recommendations for future work. The report details discussions from a series of meetings where members revisited and shared perspectives on previously discussed topics. Additionally, the report highlights members' reflections on their experience with the panel and their suggestions for future initiatives.
Citation: Yaideliz M. Romero-Ramos, Carolyn A. Malone, Kerry Finegan, Willetha Barnette, Bart Brammer, Katie Brandt, Roberta Cruz, Monica Downer, Darrell Foss, Ying-Ling Jao, LuPita Gutierrez-Parker, Freddye G. James, Joan Monin, Emily Mroz, Maria Mora Pinzon, Judith S. Rocha, Lauren Stratton, Mark Toles, Anthony Wagner, Monica Moreno, Gary Epstein-Lubow. The IMPACT Collaboratory Lived Experience Panel: Reflections on Accomplishments and Recommendations for Continued Work. NIA IMPACT Collaboratory; 2024. https://doi.org/10.58234/52377846
Using pragmatic trials to address prescription safety in older patients with diabetes
November 2025 - In Grand Rounds 60, Richard W. Grant, MD, MPH discusses "Using pragmatic trials to address prescription safety in older patients with diabetes."
Speakers
Richard W. Grant, MD, MPH
Research Scientist
Kaiser Permanente Division of Research, Kaiser Permanente Northern California
Learning Objectives
- Understand how pragmatic clinical trials improve prescription safety for older adults with diabetes
- Explore deprescribing strategies and barriers in diabetes care
- Review key findings from the RETRO-DM and SAGE studies
- Learn practical interventions for safer diabetes management, including academic detailing and technology-enabled hypoglycemia prevention
Building the NEXT STEPs Network
October 2025 – In Grand Rounds 59, Kathleeen Unroe, MD, MHA, MS discusses “Building the NEXT STEPs Network.”
Speaker
Kathleen Unroe, MD, MHA, MS (she/hers)
CEO
Probari, Inc.
Learning Objectives
- Understand the need for rigorous clinical trials and research infrastructure to improve nursing home care
- Recognize the importance of building collaborative networks and partnerships to address knowledge gaps in nursing home research
- Reflect on strategies and resources for supporting equitable, high-quality clinical trials in nursing homes, including recruitment, retention, and engagement of diverse stakeholders
