RWD Scholars headshots

Bridging Research and Practice: An Update from Real World Data Scholars

May 2025 – In Grand Rounds 56, the 2023 Real World Data Scholars presented on their research projects using the Long-Term Care (LTC) Data Cooperative dataset.

Webinar Slides

Headshot of Jinying Chen, PhD from the shoulders upJinying Chen, PhD

Boston University Chobanian & Avedisian School of Medicine

Validating Medication Orders by Leveraging Natural Language Processing

Headshot of Kenneth Lam, MD, MAS from the shoulders up, smiling and wearing a suit.

Kenneth Lam, MD, MAS  

University of Colorado
School of Medicine

Validation of Functional Measures in LTC EHR Data

Headshot of Lindsay White from the shoulders up.Lindsay White, PhD

University of Pennsylvania Perelman School of Medicine

Determination of Cognitive Status in NH Residents: The Utility of EHR Data

Headshot of Yongkang Zhang, Phd, MS from the shoulders up.

Yongkang Zhang, PhD, MS 

Weill Cornell Medical College

Evaluating LTC Data Cooperative EHRs to Study T2D among Nursing Home Residents

Dr. Possin Grand Rounds card

Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the TabCAT Brain Health Assessment

April 2025 – In Grand Rounds 55, Katherine Possin, PhD, discusses "Augmenting Nurse Support and Electronic Health Record (EHR) Integration for the Pragmatic Trial of the TabCAT Brain Health Assessment (TabCAT-BHA)." TabCAT-BHA is a software platform owned by UCSF to provide diagnosis in MCI and dementia.

Speakers

Katherine Possin, PhD

Katherine Possin, PhD
John Douglas French Alzheimer’s Foundation Endowed Professorship
Professor in Residence
Department of Neurology
UCSF Memory and Aging Center

Learning Objectives

  • Learn about the DetectCID Consotrium and TabCAT-Brain Health Assessment
  • Understand implementation of TabCAT-BHA as part of a diagnostic care pathway at UCSF primary care (DetectCID-1) and Kaiser Permanente Southern California primary care (DetectCID-2)
  • Understand scaling TabCAT-BHA & Brain Health Consultation

 

Improving Advance Care Planning for Seriously Ill Primary Care Patients: UC Health Care Planning Study

January 2025 - In Grand Rounds 52, Rebecca Sudore, MD, and Anne Walling, MD, PhD, present on "Improving Advance Care Planning (ACP) for Seriously Ill Primary Care Patients: UC Health Care Planning Study". They discuss the evolving ACP definition and research, along with lessons learned from their ACP PCORI pragmatic randomized control trial.

Speakers

Rebecca Sudore, MDRebecca Sudore, MD
Professor of Medicine,
University of California,
San Francisco

Anne Walling, MD, PhDAnne Walling, MD, PhD
Professor-in-Residence,
University of California,
Los Angeles

Learning Objectives

  • The Evolving ACP Definition & Research
  • Lessons for an ACP PCORI Pragmatic RCT
    • Identifying the cohort with validated algorithms
    • Constructing the ACP EMR Intervention Infrastructure
    • Healthcare navigator arm
    • Trial outcomes: NLP
    • Implementation Lessons

Guidance for Proxy Data and Dyadic Analysis

May 17, 2024

Authors: Katie Newkirk, PhD and Joan Monin, PhD

Description: This document provides guidance on what dyadic data is, how it is different from proxy data, and what information can be gained by collecting and analyzing dyadic data compared to proxy data when conducting embedded pragmatic clinical trials (ePCTs) that include people living with dementia and care partners. Topic covered:

  • Dyadic Data
  • Proxy Data
  • Constructs Often Measured for Both People Living with Dementia and Care Partners
  • Analyzing Dyadic Data
  • When Data Don’t Require Dyadic Analysis
  • Proxy Data
  • Do I Have Dyadic Data?
Citation: Newkirk K, Monin J. Guidance for Proxy Data and Dyadic Analysis. NIA IMPACT Collaboratory; 2024. doi: 10.58234/236781742
Click to view PDF of Guidance for Proxy Data and Dyadic Analysis

Observing the impact of personalized music on agitated behaviors in dementia patients

Using Structured Observations to Evaluate the Effects of a Personalized Music Intervention on Agitated Behaviors and Mood in Nursing Home Residents With Dementia: Results From an Embedded, Pragmatic Randomized Controlled Trial

November 2, 2023

Authors, including IMPACT members, Roee Gutman, PhD, Vincent Mor, PhD, James Rudolph, MD, SM, Rosa Baier, MPH, and Ellen McCreedy, PhD, MPH explored whether implementation of a personalized music intervention decreased the frequency of agitated behaviors in nursing home residents with dementia. They measured impact by using structured observations conducted as part of a randomized controlled trial design.

The authors found that personalized music decreased the frequency of verbally agitated behaviors in residents randomized to receive the treatment compared to residents randomized to a usual care control. No effect of the intervention was found on physically agitated behaviors. The intervention also increased observed pleasure.

This study provides evidence for the effectiveness of a non-pharmacological intervention for temporary relief in verbal behaviors in nursing home residents with dementia.

Read the full article.

American Journal of Bioethics publishes special issue, includes commentary on article by IMPACT member

July 14, 2023

A previously published article by IMPACT member Emily Largent, PhD, JD, RN, and Stephanie Morain, MD, was the subject of guest commentary in a special issue of The American Journal of Bioethics (AJOB). The special issue focused on pragmatic clinical trials (PCTs). In the issue, Largent and Morain’s target article exploring investigators’ ethical obligations to patients was discussed in several peer commentaries and by two guest editorials including one co-authored by Commissioner of the Food and Drug Administration (FDA), Robert Califf, MD.

 

Access the special issue including all commentaries and the original target article.

IMPACT Collaboratory announces the 2023 Health Care Systems Scholars Program Awardees

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is pleased to announce the 2023 Health Care Systems (HCS) Scholars Program awardees.

This program offers investigators an opportunity to work directly with health care systems interested in improving the care provided to people living with dementia (PLWD) and their care partners. The goals of the HCS Scholars Program are to embed investigators in health care systems to:

  • Establish mutually beneficial partnerships to improve the care of PLWD and their care partners.
  • Train investigators about health care settings’ needs and how new programs are successfully introduced at all levels of the organization.
  • Engage HCS in learning more about what it means to conduct ePCTs and provide resources for understanding opportunities for improvement in dementia care or evaluation of related quality improvement projects.
  • Strengthen collaborations between investigators and HCS that may lead to pilot studies or demonstration projects.

Recipients of this year’s HCS Scholar awards are:

Co-Designing Care Transition Support for Dementia Patients and Care Partners             

Building an Academic Long-Term Care System Coalition to Improve Palliative Care

IMPACT’s Mor is among authors of JAMA article on hospital discharge rates and nursing home quality for those with dementia

IMPACT multiple principal investigator Vincent Mor, PhD recently co-authored an article in Journal of American Medical Association (JAMA) Network Open sharing results of a cross-sectional analysis of Medicare beneficiaries.

The JAMA Network Open article shares a cross-sectional analysis of more than 2 million Medicare beneficiaries hospitalized between 2017 and 2019. The analysis revealed that persons with Alzheimer’s Disease and Related Dementia were more likely to be discharged to lower-quality Skilled Nursing Facilities (SNF) after accounting for discharging hospital, residential neighborhood, and other characteristics (e.g., post-acute care specialization) of all SNFs available at discharge. Results were consistent in analyses stratified by race and ethnicity, payer source, and primary diagnosis.

The article was also covered in McKnight’s to emphasize how the study results show that regulatory and payment changes are “badly needed” to improve the care process and support direct care staff working with dementia patients.

The McKnight article emphasized how the results should cause policymakers to consider incentivizing nursing homes to take patients with Alzheimer’s disease and related dementias (ADRD). The study data showed that these patients often end up in low-quality facilities after a hospital stay. Mor and his colleagues suggested that improving nursing home quality for patients with ADRD will require focused funding efforts to provide quality care.